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Umbilical cord stem cells injected into shoulder to heal torn tendon

NCT ID NCT06794294

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether stem cells from donated umbilical cords can safely help heal partial rotator cuff tears. 21 adults with shoulder pain for at least 3 months who haven't improved with other treatments will receive a single injection of stem cells into the tear. Researchers will measure pain and shoulder function over time to see if it works.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
umbilical cord derived mesenchymal stem cells
What this could lead to
If it works, this could point toward a non-surgical treatment for partial rotator cuff tears, potentially reducing pain and improving shoulder function.
What could go wrong
This is a very early phase 1/2a trial with only 21 people, so results may not apply to everyone. The stem cells could cause side effects like injection site reactions or fail to improve symptoms.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 21 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female 19 years of age and older. * Patients with unilateral shoulder pain lasting for at least 3months * Patients who do not respond to conservative treatment. * Patients who have not responded to sufficient non-surgical treatments, including medication, injection therapy, physical therapy, or exercise therapy, for more than 3 months * Patients who have a partial-thickness rotator cuff tear confirmed with magnetic resonance imaging (MRI) or ultrasonography (US). * Patients without any restrictions on clinical trial procedures, including hospitalization. Exclusion Criteria: * Patients who have received subacromial injection therapy on the affected shoulder within the past 3 months. * Patients who have undergone rotator cuff surgery on the affected shoulder within the past 6 months * Patients with a history of receiving stem cell therapy for the shoulder. * Patients with the following shoulder conditions: complete rotator cuff tear, adhesive capsulitis, or isolated acromioclavicular joint arthropathy. * Patients showing or suspected of having the following radiological findings: malignancy, severe osteoarthritis of the glenohumeral joint, or skeletal abnormalities decreasing the subacromial space. * Patients presenting with symptomatic cervical spine disorders. * Patients with concurrent bilateral shoulder pain * Patients with polyarthritis, infectious arthritis, rheumatoid arthritis, or fibromyalgia. * Patients with neurological deficit * Pregnant women or lactating mothers. * Patients unwilling to use effective contraception during the clinical trial period. * Patients with current HBV, HCV, or HIV infections, or those with a positive RPR test. * Patients with severe diseases that may affect the clinical trial, including cardiovascular disease, renal disease, liver disease, endocrine disorders, or malignancies. * Patients who are unable to understand the questionnaires used for assessing their clinical status, including the Visual Analogue Scale (VAS), or those with psychiatric disorders impairing communication. * Patients who do not wish to participate in the clinical trial or are unable to comply with follow-up schedules. * Patients who have participated in another clinical trial within the last 3 months. * Patients deemed unsuitable for participation in this clinical trial at the investigator's discretion

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Joint & Spine Center, SMG-SNU Boramae Medical Center, Department of Orthopedic Surgery, Seoul National University College of Medicine

    RECRUITING

    Seoul, Korea, 07061, South Korea

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