Umbilical cord stem cells injected into shoulder to heal torn tendon
NCT ID NCT06794294
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether stem cells from donated umbilical cords can safely help heal partial rotator cuff tears. 21 adults with shoulder pain for at least 3 months who haven't improved with other treatments will receive a single injection of stem cells into the tear. Researchers will measure pain and shoulder function over time to see if it works.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- umbilical cord derived mesenchymal stem cells
- What this could lead to
- If it works, this could point toward a non-surgical treatment for partial rotator cuff tears, potentially reducing pain and improving shoulder function.
- What could go wrong
- This is a very early phase 1/2a trial with only 21 people, so results may not apply to everyone. The stem cells could cause side effects like injection site reactions or fail to improve symptoms.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1/2
Runs two stages together: safety and dose first, then whether the treatment works.
- Participants
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About 21 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2025
- Expected to finish
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Jan 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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19 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male or female 19 years of age and older. * Patients with unilateral shoulder pain lasting for at least 3months * Patients who do not respond to conservative treatment. * Patients who have not responded to sufficient non-surgical treatments, including medication, injection therapy, physical therapy, or exercise therapy, for more than 3 months * Patients who have a partial-thickness rotator cuff tear confirmed with magnetic resonance imaging (MRI) or ultrasonography (US). * Patients without any restrictions on clinical trial procedures, including hospitalization. Exclusion Criteria: * Patients who have received subacromial injection therapy on the affected shoulder within the past 3 months. * Patients who have undergone rotator cuff surgery on the affected shoulder within the past 6 months * Patients with a history of receiving stem cell therapy for the shoulder. * Patients with the following shoulder conditions: complete rotator cuff tear, adhesive capsulitis, or isolated acromioclavicular joint arthropathy. * Patients showing or suspected of having the following radiological findings: malignancy, severe osteoarthritis of the glenohumeral joint, or skeletal abnormalities decreasing the subacromial space. * Patients presenting with symptomatic cervical spine disorders. * Patients with concurrent bilateral shoulder pain * Patients with polyarthritis, infectious arthritis, rheumatoid arthritis, or fibromyalgia. * Patients with neurological deficit * Pregnant women or lactating mothers. * Patients unwilling to use effective contraception during the clinical trial period. * Patients with current HBV, HCV, or HIV infections, or those with a positive RPR test. * Patients with severe diseases that may affect the clinical trial, including cardiovascular disease, renal disease, liver disease, endocrine disorders, or malignancies. * Patients who are unable to understand the questionnaires used for assessing their clinical status, including the Visual Analogue Scale (VAS), or those with psychiatric disorders impairing communication. * Patients who do not wish to participate in the clinical trial or are unable to comply with follow-up schedules. * Patients who have participated in another clinical trial within the last 3 months. * Patients deemed unsuitable for participation in this clinical trial at the investigator's discretion
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Joint & Spine Center, SMG-SNU Boramae Medical Center, Department of Orthopedic Surgery, Seoul National University College of Medicine
RECRUITINGSeoul, Korea, 07061, South Korea
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can we decode shoulder pain scores to improve rotator cuff care?
- Umbilical cord stem cells tested for shoulder injury
- Laser or physio: which eases shoulder pain faster?
- Could your genes predict rotator cuff tears?
- Sugar water shots ease shoulder pain in new study
- Stem cells from umbilical cords tested for shoulder pain relief