Umbilical cord stem cells tested for shoulder injury
NCT ID NCT07605559
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether injecting stem cells from umbilical cords can help heal partial rotator cuff tears in the shoulder. Thirty-eight adults with ongoing shoulder pain will receive either a high or medium dose of stem cells or a placebo. The main goal is to see if the tear shrinks on MRI scans.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- umbilical cord-derived mesenchymal stem cells
- What this could lead to
- If it works, this could offer a non-surgical way to heal partial rotator cuff tears and reduce shoulder pain.
- What could go wrong
- This is a small, early-stage trial with only 38 participants. The stem cells may not repair the tear, and there is a risk of injection-related side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 38 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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May 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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19 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults aged 19 years or older * Shoulder pain lasting for at least 3 months * A pain visual analogue scale (VAS) score of 4 or greater * Inadequate response to sufficient conservative treatment for at least 3 months, such as medication, injection therapy, physical therapy, or exercise therapy * Partial-thickness rotator cuff tear confirmed by ultrasonography or magnetic resonance imaging (MRI) * No restrictions on participation in clinical trial procedures, including hospitalization Exclusion Criteria: * Receipt of subacromial injection therapy in the affected shoulder within the past 3 months * History of rotator cuff surgery on the affected shoulder within the past 6 months * Previous treatment with a stem cell therapy for the shoulder * Presence of any of the following shoulder conditions: full-thickness rotator cuff tear, obvious isolated acromioclavicular joint arthropathy, or a clear history of trauma to the shoulder joint within the past 3 months * Radiologic findings suggestive of or consistent with any of the following: malignancy, severe glenohumeral osteoarthritis, bony abnormalities causing narrowing of the subacromial space, or clear evidence of acute traumatic rotator cuff injury * Presence of symptomatic cervical spine disease * Patients with polyarthritis, infectious arthritis, rheumatoid arthritis, or fibromyalgia * Clinical trial subjects with neurological deficits * Pregnant or breastfeeding women * Unwillingness to use an effective method of contraception during participation in the clinical trial * Presence of any serious disease that may affect participation in this clinical trial, including cardiovascular, renal, hepatic, endocrine, or neoplastic disease * Inability to understand the questions used to assess the subject's condition, including the visual analogue scale (VAS), or communication difficulties due to psychiatric illness * Unwillingness to participate in the clinical trial or difficulty in complying with follow-up visits according to the study schedule * Participation in another clinical trial within 3 months prior to enrollment in this clinical trial * Any other condition that, in the opinion of the investigator, makes the subject unsuitable for participation in this clinical trial
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Asan Medical Center
Seoul, Seoul, 05505, South Korea
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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