Can stronger, targeted radiation beat brain metastases without Whole-Brain side effects?
NCT ID NCT02645487
First seen Feb 21, 2026 · Last updated Jun 23, 2026 · Updated 17 times
Summary
This study tests whether giving higher doses of focused radiation (stereotactic radiosurgery) to brain tumors is safe and effective, without also radiating the whole brain. About 135 adults with certain types of cancer that have spread to the brain will receive escalating radiation doses based on tumor size. The goal is to find the highest tolerable dose that may improve tumor control and survival while preserving quality of life.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Stereotactic Radiosurgery (SRS)
What this could lead to
If successful, this could establish safer, more effective radiation doses for brain metastases, potentially improving local tumor control and survival without whole-brain radiation.
What could go wrong
This is an early dose-escalation study, so the highest doses may prove too toxic. The trial is also limited to patients with certain tumor types and no prior brain radiation.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.