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Saliva test reveals smoking and gum disease worsen cell damage

NCT ID NCT07279896

Knowledge-focused Sponsor: Zehra Hasgül Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether smoking and severe gum disease (Stage III periodontitis) increase damage to DNA and RNA in cells. Researchers measured two markers of oxidative stress in saliva from 88 adults, including smokers and non-smokers with and without gum disease. They found that people with gum disease had higher damage levels, and smokers with gum disease had the highest. The findings suggest a simple saliva test could help detect gum disease and show how smoking adds to cell stress.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

88 people

The number who actually took part.

Started

May 2025

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consisted of systemically healthy adults aged 18-65 years, including individuals with Stage III periodontitis and periodontally healthy controls. Participants were categorized into four groups based on periodontal status and smoking habits: smokers and non-smokers with Stage III periodontitis, and smokers and non-smokers who were periodontally healthy.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals aged 18 years or older * Having at least 16 permanent teeth, excluding third molars * Not using orthodontic appliances * Not pregnant or breastfeeding * Systemically healthy individuals with no systemic diseases that could affect periodontal status * No use of anti-inflammatory or antimicrobial medications within the last 6 months * No periodontal treatment within the last 12 months Exclusion Criteria: * Pregnant or breastfeeding individuals. * Use of anti-inflammatory or antimicrobial drugs in the past 6 months. * Use of antioxidant supplements in the past 3 months. * Periodontal treatment within the past 12 months. * Diagnosis of psychiatric disorders. * Any oral infection. * Fewer than 16 permanent teeth (excluding third molars). * Alcohol dependence. * Active infectious diseases (Acute hepatitis, AIDS, tuberculosis), malignancy, or any systemic condition that may affect periodontal tissues. * Current use of medications known to affect periodontal tissues (phenytoin, cyclosporine A, calcium channel blockers).

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Conditions

The condition(s) this trial relates to.

periodontitis Smoking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontitis (stage 3) Smoking

Contacts and locations

Locations

  • Ankara University Faculty of Dentistry, Department of Periodontology

    Ankara, Yenimahalle, 06560, Turkey (Türkiye)

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