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Can incentives and outreach get smokers to try quitting? new study tests four strategies.

NCT ID NCT04199117

Disease control Sponsor: University of Wisconsin, Madison Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested four health system strategies to encourage adult smokers who weren't ready to quit to start using evidence-based treatments. The strategies included small financial rewards, personalized mailings, proactive phone calls from a tobacco care manager, and free counseling with nicotine replacement or varenicline. Over 1,600 primary care patients were followed for two years to see if these approaches increased treatment use and helped them quit smoking.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Varenicline and combination nicotine patch and mini-lozenge
What this could lead to
If successful, this could show health systems how to encourage more smokers to use proven treatments and quit for good.
What could go wrong
This is a completed Phase 4 study focused on treatment initiation, not a cure. Results may not apply to all smokers, and the interventions may not lead to long-term abstinence.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

210 people

The number who actually took part.

Started

Mar 2020

Finished

Oct 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * Primary care patient who receives care at one of the host family medicine or internal medicine clinics * \>17 years old * Report smoking 7 of the last 7 days at enrollment * Report smoking at least five cigarettes per day for at least 6 months at enrollment * Able to speak and read English Exclusion criteria: * Opted out of Care Manager outreach at the most recent clinic visit or by phone * Willing to quit smoking within 30 days (these patients will be referred for immediate treatment rather than enrolled in this study) * Inability to use both C-NRT and varenicline due to a contraindication to both treatments at enrollment (allergic reactions, severe renal disease) * Current treatment for schizophrenia or a psychotic disorder at enrollment * History of suicide attempt in the past 10 years at enrollment

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Conditions

The condition(s) this trial relates to.

Cigarette Smoking Smoking Cessation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Smoking cessation Smoking, cigarette

Contacts and locations

Locations

  • UW Center for Tobacco Research and Intervention

    Madison, Wisconsin, 53711, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.