New study tests sleep pills to boost knee surgery recovery
NCT ID NCT07598734
First seen Jun 05, 2026 · Last updated Jun 23, 2026 · Updated 4 times
Summary
This study tests whether the sleep aids doxepin and ramelteon can improve sleep quality during the first 6 weeks after total knee replacement. About 129 adults will be randomly assigned to take doxepin alone, doxepin plus ramelteon, or a placebo pill each night. The goal is to see if better sleep leads to less pain, better knee function, and improved quality of life.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Washington Medical Center Hip & Knee Center
Seattle, Washington, 98133, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
doxepin and ramelteon
What this could lead to
If it works, this could provide a safe, effective option to improve sleep and recovery after knee replacement surgery.
What could go wrong
This is a small, early-phase trial (129 people) testing drugs for a short period. Results may not apply to everyone, and side effects or lack of benefit are possible.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.