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Could a common ED drug shield the brain from silent damage?

NCT ID NCT03855332

First seen Nov 19, 2025 · Last updated May 21, 2026 · Updated 27 times

Summary

This study tested whether sildenafil (the drug in Viagra) can reduce harmful blood flow pulsations in the brains of 75 people who had a stroke or mini-stroke due to small vessel disease. Participants took sildenafil, a similar drug, and a placebo for three weeks each, in random order. The goal was to see if opening blood vessels could protect the brain and potentially slow down small vessel disease, which affects many older adults and contributes to stroke and dementia.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • University of Oxford

    Oxford, Oxon, OX39DU, United Kingdom

Conditions

Explore the condition pages connected to this study.