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Kidney shield? sedative drug may protect against Surgery-Related kidney damage

NCT ID NCT06835010

Disease control Sponsor: Tanta University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether adding the sedative dexmedetomidine to sevoflurane anesthesia could help prevent acute kidney injury after non-cardiac surgery. Researchers enrolled 90 patients undergoing total knee replacement. They measured changes in kidney function by checking blood creatinine levels. The goal was to see if dexmedetomidine offers kidney protection through immune and antioxidant effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Dexmedetomidine (a sedative drug) and sevoflurane (an inhaled anesthetic)
What this could lead to
If it works, this could point toward a way to reduce the risk of acute kidney injury after major surgery.
What could go wrong
This is a small, completed study with only 90 participants, all women, so results may not apply to men or larger populations. The findings are preliminary and need confirmation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

90 people

The number who actually took part.

Started

May 2024

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 70 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients who were assigned for TKR surgery; * Patients with preoperative serum creatinine (SCr) levels of \<1.1 mg/ml; * Patients with controlled medical conditions; * Patients free of exclusion criteria were enrolled in the study. Exclusion Criteria: * Male patients were excluded to guard against the impact of senile prostatic hypertrophy on kidney functions; * Patients who had preoperative SCr of \>1.1 mg/dl; * Presence of any urological disorders, urological stone diseases; * Patients with autoimmune diseases, medical disorders requiring maintenance on immunosuppressant therapy; * Patients with cancer anywhere in the body were excluded.

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Conditions

The condition(s) this trial relates to.

acute kidney injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AKI - acute kidney injury

Contacts and locations

Locations

  • Tanta University

    Tanta, El Gharbyia, 13511, Egypt

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