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New drug combo aims to outsmart recurrent ovarian cancer

NCT ID NCT05554328

Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 22 times

Summary

This phase 2 trial tests whether adding olaparib to selumetinib works better than selumetinib alone for women with recurrent or persistent ovarian or endometrial cancers that have a RAS pathway mutation. Selumetinib blocks enzymes that help cancer grow, while olaparib stops cancer cells from repairing their DNA. The study will enroll 165 participants and measure how long the cancer stays under control.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Selumetinib and olaparib
What this could lead to
If it works, this combination could offer a new targeted treatment option that shrinks tumors or keeps them stable longer in women with these hard-to-treat cancers.
What could go wrong
This is a mid-stage trial with only 165 participants, so results may not apply to everyone. Adding olaparib could also increase side effects without improving outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 165 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2023

Expected to finish

Oct 2028

An estimate. End dates often move.

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient must have enrolled onto EAY191 and must have been given a treatment assignment to ComboMATCH to EAY191-N4 based on the presence of an actionable mutation as defined in EAY191 * Patients must be enrolled on the ComboMATCH Master Registration Trial EAY191 * Patients must have RAS pathway mutations as determined by the ComboMATCH screening assessment * Cohort 1: Patients with histologically confirmed RAS pathway mutant ovarian, primary peritoneal, or fallopian tube ("ovarian") cancer (activating mutations in KRAS, NRAS, HRAS, BRAF, MEK1, MEK2, or inactivating mutations in NF1) * Cohort 2: Patients with histologically confirmed RAS pathway mutant endometrial cancer (activating mutations in KRAS, NRAS, HRAS, BRAF, MEK1, MEK2, or inactivating mutations in NF1) * Patients must have disease that can be safely biopsied and agree to a pre-treatment biopsy or, if disease cannot be safely biopsied, have archival tissue available from within 12 months prior to the date of registration on the ComboMATCH Registration Trial (EAY191) * Patients must have progressed after first-line treatment for recurrent or persistent disease * Patients with ovarian cancer should not be eligible for further platinum-based therapy * Patients with endometrial cancer must have received or been offered an immune oncology agent (alone or in combination with lenvatinib) unless there are existing contraindications for immune oncology agents or lenvatinib * Patients may have received unlimited prior therapy * Patients must have measurable and biopsiable disease. Measurable disease is defined by RECIST 1.1 as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded). Each lesion must be \> 10 mm when measured by CT, magnetic resonance imaging (MRI) or caliper measurement by clinical exam; or \> 20 mm when measured by chest x-ray. Lymph nodes must be \> 15 mm in short axis when measured by CT or MRI * Patients must have at least one "target lesion" separate from the lesion to be biopsied to be used to assess response on this protocol as defined by RECIST version 1.1. Tumors within a previously irradiated field will be designated as "non-target" lesions unless progression is documented or a biopsy is obtained to confirm persistence at least 90 days following completion of radiation therapy * Prior therapy must have been completed at least four weeks prior to registration * Age \>= 18 * Eastern Cooperative Oncology Group (ECOG) Performance Status of 0, 1 or 2 * Hemoglobin (Hgb) \>= 9.5 g/dL with no blood transfusion in the past 28 days (within 14 days prior to registration) * Platelets \>= 100,000/mcl (within 14 days prior to registration) * Absolute neutrophil count (ANC) \>= 1,500/mcl (within 14 days prior to registration) * Patients must have creatinine clearance estimated of \>= 50 mL/min using the Cockcroft-Gault equation or based on a 24 hour urine test (within 14 days prior to registration) * Total bilirubin level =\< 1.5 x institutional upper limit of normal (ULN) or =\< 3 x ULN in the presence of documented Gilbert's syndrome (unconjugated hyperbilirubinemia) (within 14 days prior to registration) * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\< 3 x ULN (within 14 days prior to registration) * Patients must be able to swallow and retain oral medications and be without gastrointestinal illnesses that would preclude absorption of selumetinib or olaparib * Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better * Women of childbearing potential (WOCBP) must agree to use two forms of birth control (hormonal or barrier method of birth control; abstinence) during the study and for 6 months after completing treatment * Non-sterilized male partners of WOCBP (including males sterilized by a method other than bilateral orchidectomy e.g., vasectomy) who intend to be sexually active with a female partner must be using an acceptable method of contraception such as male condom plus spermicide (condom alone in countries where spermicides are not approved) from the time of screening throughout the total duration of the study and the drug washout period (at least 6 months after the last dose of study intervention) to prevent pregnancy in a partner. Periodic abstinence, the rhythm method, and the withdrawal method are not acceptable methods of contraception. Vasectomized (i.e., sterile) males are considered fertile and should still use a male condom plus spermicide as indicated above during the clinical study * Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial * Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months of registration are eligible for this trial * Patients with evidence of chronic hepatitis B virus (HBV) infection must have an undetectable HBV viral load on suppressive therapy, if indicated * Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load * Patients with new or progressive brain metastases (active brain metastases) or leptomeningeal disease are eligible if the treating physician determines that immediate central nervous system (CNS) specific treatment is not required and is unlikely to be required during the first cycle of therapy * Patients with treated brain metastases are eligible if follow-up brain imaging after CNS-directed therapy shows no evidence of progression * Extra caution should be taken with olaparib, as it crosses the blood brain barrier and can cause edema in brain metastases * The patient or a legally authorized representative must provide study-specific informed consent prior to study entry and, for patients treated in the United States (U.S.), authorization permitting release of personal health information Exclusion Criteria: * Patients who have received any MEK inhibitors * Patients who have progressed while receiving a PARP inhibitor * Patients who have received chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to registration * Patients who have not recovered from adverse events due to prior anti-cancer therapy (i.e., have residual toxicities \> grade 1) with the exception of alopecia * Patients with uncontrolled intercurrent illness * Patients with \>= grade 2 neuropathy within 14 days of registration * Patients with severe (Child-Pugh C) liver dysfunction * Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to olaparib and selumetinib or any excipients thereof * Concomitant use of known strong (e.g., phenobarbital, enzalutamide, phenytoin, rifampicin, rifabutin, rifapentine, carbamazepine, nevirapine and St John's Wort) or moderate CYP3A inducers (e.g., bosentan, efavirenz, modafinil). The required washout period prior to starting olaparib is 5 weeks for enzalutamide or phenobarbital and 3 weeks for other agents * Supplementation with vitamin E greater than 100% of the daily recommended dose. Any multivitamin containing vitamin E must be stopped prior to study enrollment even if less than 100% of the daily recommended dosing for vitamin E * Vitamin E must not be taken in the 7 days prior to initiation of treatment with selumetinib * Concomitant use of known strong CYP3A inhibitors (e.g., itraconazole, telithromycin, clarithromycin, protease inhibitors boosted with ritonavir or cobicistat, indinavir, saquinavir, nelfinavir, boceprevir, telaprevir) or known moderate CYP3A inhibitors (e.g. ciprofloxacin, erythromycin, diltiazem, Fluconazole, verapamil). The required washout period prior to starting olaparib is at least 14 days or 5 half-lives (whichever is longer) before the first dose of study medication * Concomitant use of strong CYP2C19 inhibitors (e.g., ticlopidine) or moderate CYP2C19 inhibitors (e.g., omeprazole). The required washout period prior to starting selumetinib is at least 14 days or 5 half-lives (whichever is longer) before the first dose of study medication * Have received or are receiving an investigational medicinal product (IMP) or other systemic anti-cancer treatment (including chemotherapy, immunotherapy, targeted therapy, biologic therapy, tumor embolization, or monoclonal antibodies) within 4 weeks prior to registration, or within a period during which the IMP or systemic target treatment has not been cleared from the body (e.g., a period of 5 'half-lives'), whichever is longer * Known myelodysplastic syndrome/acute myeloid leukemia or with features suggestive of myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) * Patients who have had previous organ transplant, allogenic bone marrow transplant or double umbilical cord blood transplantation * Patients who have had whole blood transfusion within 28 days prior to registration * Patients with ophthalmological conditions as follows: * Current or past history of retinal pigment epithelial detachment/central serous retinopathy or retinal vein occlusion. * Intraocular pressure \> 21 mmHg (or ULN adjusted by age) or uncontrolled glaucoma (irrespective of intraocular pressure \[IOP\]). Subjects with known glaucoma and increased IOP who do not have meaningful vision (light perception only or no light perception) and are not experiencing pain related to the glaucoma, may be eligible after discussion with the study chair * Patients with any other significant abnormality on ophthalmic examination should be discussed with the study chair for potential eligibility * Ophthalmological findings secondary to long-standing optic pathway glioma (such as visual loss, optic nerve pallor or strabismus) or longstanding orbito-temporal plexiform neurofibroma (PN) (such as visual loss, strabismus) will NOT be considered a significant abnormality for the purposes of the study * Patients with severe, active co-morbidity defined as any of the following: * History and/or confirmed pneumonitis * Uncontrolled hypertension (blood pressure \[BP\] \>= 150/90 mmHg despite medical therapy) * Acute coronary syndrome within 6 months prior to registration * Uncontrolled atrial fibrillation * Known family history of long QT syndrome * Women who are pregnant or unwilling to discontinue nursing

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Conditions

The condition(s) this trial relates to.

endometrial cancer endometrial carcinoma endometrium neoplasm fallopian tube carcinoma fallopian tube neoplasm ovarian cancer ovarian carcinoma primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Recurrent endometrial carcinoma Recurrent fallopian tube carcinoma Recurrent ovarian carcinoma Recurrent primary peritoneal carcinoma

Contacts and locations

Locations

  • AMG Crystal Lake - Oncology

    Crystal Lake, Illinois, 60014, United States

  • AMG Libertyville - Oncology

    Libertyville, Illinois, 60048, United States

  • Abbott-Northwestern Hospital

    Minneapolis, Minnesota, 55407, United States

  • Adena Regional Medical Center

    Chillicothe, Ohio, 45601, United States

  • Advocate Christ Medical Center

    Oak Lawn, Illinois, 60453-2699, United States

  • Advocate Good Samaritan Hospital

    Downers Grove, Illinois, 60515, United States

  • Advocate Good Shepherd Hospital

    Barrington, Illinois, 60010, United States

  • Advocate Illinois Masonic Medical Center

    Chicago, Illinois, 60657, United States

  • Advocate Lutheran General Hospital

    Park Ridge, Illinois, 60068, United States

  • Advocate Sherman Hospital

    Elgin, Illinois, 60123, United States

  • Advocate South Suburban Hospital

    Hazel Crest, Illinois, 60429, United States

  • Alaska Women's Cancer Care

    Anchorage, Alaska, 99508, United States

  • Annie Penn Memorial Hospital

    Reidsville, North Carolina, 27320, United States

  • Asplundh Cancer Pavilion

    Willow Grove, Pennsylvania, 19090, United States

  • Atrium Medical Center-Middletown Regional Hospital

    Franklin, Ohio, 45005-1066, United States

  • Aultman Health Foundation

    Canton, Ohio, 44710, United States

  • Aurora Bay Area Medical Group-Marinette

    Marinette, Wisconsin, 54143, United States

  • Aurora BayCare Medical Center

    Green Bay, Wisconsin, 54311, United States

  • Aurora Cancer Care-Grafton

    Grafton, Wisconsin, 53024, United States

  • Aurora Cancer Care-Kenosha South

    Kenosha, Wisconsin, 53142, United States

  • Aurora Cancer Care-Milwaukee

    Milwaukee, Wisconsin, 53209, United States

  • Aurora Cancer Care-Milwaukee West

    Wauwatosa, Wisconsin, 53226, United States

  • Aurora Cancer Care-Racine

    Racine, Wisconsin, 53406, United States

  • Aurora Cancer Care-Southern Lakes VLCC

    Burlington, Wisconsin, 53105, United States

  • Aurora Health Care Germantown Health Center

    Germantown, Wisconsin, 53022, United States

  • Aurora Medical Center in Summit

    Summit, Wisconsin, 53066, United States

  • Aurora Saint Luke's Medical Center

    Milwaukee, Wisconsin, 53215, United States

  • Aurora Saint Luke's South Shore

    Cudahy, Wisconsin, 53110, United States

  • Aurora Sinai Medical Center

    Milwaukee, Wisconsin, 53233, United States

  • Aurora West Allis Medical Center

    West Allis, Wisconsin, 53227, United States

  • Baystate Medical Center

    Springfield, Massachusetts, 01199, United States

  • Benefis Sletten Cancer Institute

    Great Falls, Montana, 59405, United States

  • Billings Clinic Cancer Center

    Billings, Montana, 59101, United States

  • Bozeman Health Deaconess Hospital

    Bozeman, Montana, 59715, United States

  • Bryn Mawr Hospital

    Bryn Mawr, Pennsylvania, 19010, United States

  • CTCA at Western Regional Medical Center

    Goodyear, Arizona, 85338, United States

  • Cancer Care Center of O'Fallon

    O'Fallon, Illinois, 62269, United States

  • Cancer Care Specialists of Illinois - Decatur

    Decatur, Illinois, 62526, United States

  • Cancer Center of Western Wisconsin

    New Richmond, Wisconsin, 54017, United States

  • Cancer Hematology Centers - Flint

    Flint, Michigan, 48503, United States

  • Carilion Roanoke Memorial Hospital

    Roanoke, Virginia, 24033, United States

  • Carle BroMenn Medical Center

    Normal, Illinois, 61761, United States

  • Carle Cancer Center

    Urbana, Illinois, 61801, United States

  • Carle Cancer Institute Normal

    Normal, Illinois, 61761, United States

  • Carle Physician Group-Effingham

    Effingham, Illinois, 62401, United States

  • Carle Physician Group-Mattoon/Charleston

    Mattoon, Illinois, 61938, United States

  • Carle at The Riverfront

    Danville, Illinois, 61832, United States

  • Case Western Reserve University

    Cleveland, Ohio, 44106, United States

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90048, United States

  • Centralia Oncology Clinic

    Centralia, Illinois, 62801, United States

  • Centro Comprensivo de Cancer de UPR

    San Juan, 00927, Puerto Rico

  • Chelsea Hospital

    Chelsea, Michigan, 48118, United States

  • Community Hospital of Anaconda

    Anaconda, Montana, 59711, United States

  • Community Medical Center

    Missoula, Montana, 59804, United States

  • Condell Memorial Hospital

    Libertyville, Illinois, 60048, United States

  • Cone Health Cancer Center

    Greensboro, North Carolina, 27403, United States

  • Cone Health Cancer Center at Alamance Regional

    Burlington, North Carolina, 27215, United States

  • Cone Health Cancer Center at Drawbridge Parkway

    Greensboro, North Carolina, 27410, United States

  • Cone Health MedCenter Asheboro

    Asheboro, North Carolina, 27205, United States

  • Corewell Health Beaumont Troy Hospital

    Troy, Michigan, 48085, United States

  • Corewell Health Dearborn Hospital

    Dearborn, Michigan, 48124, United States

  • Corewell Health Farmington Hills Hospital

    Farmington Hills, Michigan, 48336, United States

  • Corewell Health William Beaumont University Hospital

    Royal Oak, Michigan, 48073, United States

  • Crossroads Cancer Center

    Effingham, Illinois, 62401, United States

  • Dayton Physician LLC - Englewood

    Dayton, Ohio, 45415, United States

  • Decatur Memorial Hospital

    Decatur, Illinois, 62526, United States

  • Dublin Methodist Hospital

    Dublin, Ohio, 43016, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Duke Women's Cancer Care Raleigh

    Raleigh, North Carolina, 27607, United States

  • Duluth Clinic Ashland

    Ashland, Wisconsin, 54806, United States

  • Edwards Comprehensive Cancer Center

    Huntington, West Virginia, 25701, United States

  • Essentia Health - Deer River Clinic

    Deer River, Minnesota, 56636, United States

  • Essentia Health Cancer Center

    Duluth, Minnesota, 55805, United States

  • Essentia Health Hibbing Clinic

    Hibbing, Minnesota, 55746, United States

  • Essentia Health Sandstone

    Sandstone, Minnesota, 55072, United States

  • Essentia Health Virginia Clinic

    Virginia, Minnesota, 55792, United States

  • Fairfield Medical Center

    Lancaster, Ohio, 43130, United States

  • Fairview Clinics and Surgery Center Maple Grove

    Maple Grove, Minnesota, 55369, United States

  • Fairview Southdale Hospital

    Edina, Minnesota, 55435, United States

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, 19111, United States

  • Genesee Hematology Oncology PC

    Flint, Michigan, 48503, United States

  • Genesis Healthcare System Cancer Care Center

    Zanesville, Ohio, 43701, United States

  • Genesys Hurley Cancer Institute

    Flint, Michigan, 48503, United States

  • Good Samaritan Hospital - Cincinnati

    Cincinnati, Ohio, 45220, United States

  • Gundersen Lutheran Medical Center

    La Crosse, Wisconsin, 54601, United States

  • Harold Alfond Center for Cancer Care

    Augusta, Maine, 04330, United States

  • Henrico Doctor's Hospital

    Richmond, Virginia, 23229, United States

  • Henry Ford Saint John Hospital - Macomb Medical

    Macomb, Michigan, 48044, United States

  • Hope Women's Cancer Centers-Asheville

    Asheville, North Carolina, 28816, United States

  • Hurley Medical Center

    Flint, Michigan, 48503, United States

  • Huron Gastroenterology PC

    Ypsilanti, Michigan, 48106, United States

  • Illinois CancerCare - Washington

    Washington, Illinois, 61571, United States

  • Illinois CancerCare-Bloomington

    Bloomington, Illinois, 61704, United States

  • Illinois CancerCare-Canton

    Canton, Illinois, 61520, United States

  • Illinois CancerCare-Carthage

    Carthage, Illinois, 62321, United States

  • Illinois CancerCare-Dixon

    Dixon, Illinois, 61021, United States

  • Illinois CancerCare-Eureka

    Eureka, Illinois, 61530, United States

  • Illinois CancerCare-Galesburg

    Galesburg, Illinois, 61401, United States

  • Illinois CancerCare-Kewanee Clinic

    Kewanee, Illinois, 61443, United States

  • Illinois CancerCare-Macomb

    Macomb, Illinois, 61455, United States

  • Illinois CancerCare-Ottawa Clinic

    Ottawa, Illinois, 61350, United States

  • Illinois CancerCare-Pekin

    Pekin, Illinois, 61554, United States

  • Illinois CancerCare-Peoria

    Peoria, Illinois, 61615, United States

  • Illinois CancerCare-Peru

    Peru, Illinois, 61354, United States

  • Illinois CancerCare-Princeton

    Princeton, Illinois, 61356, United States

  • Jersey City Medical Center

    Jersey City, New Jersey, 07302, United States

  • John H Stroger Jr Hospital of Cook County

    Chicago, Illinois, 60612, United States

  • Kapiolani Medical Center for Women and Children

    Honolulu, Hawaii, 96826, United States

  • Kettering Medical Center

    Kettering, Ohio, 45429, United States

  • Kingman Regional Medical Center

    Kingman, Arizona, 86401, United States

  • Knox Community Hospital

    Mount Vernon, Ohio, 43050, United States

  • Kootenai Clinic Cancer Services - Post Falls

    Post Falls, Idaho, 83854, United States

  • Kootenai Clinic Cancer Services - Sandpoint

    Sandpoint, Idaho, 83864, United States

  • Kootenai Health - Coeur d'Alene

    Coeur d'Alene, Idaho, 83814, United States

  • Lafayette Family Cancer Center-EMMC

    Brewer, Maine, 04412, United States

  • Lankenau Medical Center

    Wynnewood, Pennsylvania, 19096, United States

  • Lehigh Valley Hospital - Muhlenberg

    Bethlehem, Pennsylvania, 18017, United States

  • Lehigh Valley Hospital-Cedar Crest

    Allentown, Pennsylvania, 18103, United States

  • Licking Memorial Hospital

    Newark, Ohio, 43055, United States

  • Logan Health Medical Center

    Kalispell, Montana, 59901, United States

  • Lyndon Baines Johnson General Hospital

    Houston, Texas, 77026-1967, United States

  • MaineHealth Maine Medical Center- Scarborough

    Scarborough, Maine, 04074, United States

  • Marietta Memorial Hospital

    Marietta, Ohio, 45750, United States

  • Mayo Clinic in Florida

    Jacksonville, Florida, 32224-9980, United States

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

  • Memorial Hospital

    Marysville, Ohio, 43040, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Commack

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Monmouth

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering Westchester

    Harrison, New York, 10604, United States

  • Mercy Health - Perrysburg Hospital

    Perrysburg, Ohio, 43551, United States

  • Mercy Health - Saint Anne Hospital

    Toledo, Ohio, 43623, United States

  • Mercy Hospital

    Coon Rapids, Minnesota, 55433, United States

  • Mercy Medical Center - Des Moines

    Des Moines, Iowa, 50314, United States

  • Miami Valley Cancer Care and Infusion

    Greenville, Ohio, 45331, United States

  • Miami Valley Hospital

    Dayton, Ohio, 45409, United States

  • Miami Valley Hospital North

    Dayton, Ohio, 45415, United States

  • Miami Valley Hospital South

    Centerville, Ohio, 45459, United States

  • Mission Hospital

    Asheville, North Carolina, 28801, United States

  • Missouri Baptist Medical Center

    St Louis, Missouri, 63131, United States

  • Missouri Baptist Sullivan Hospital

    Sullivan, Missouri, 63080, United States

  • Monmouth Medical Center

    Long Branch, New Jersey, 07740, United States

  • Monmouth Medical Center Southern Campus

    Lakewood, New Jersey, 08701, United States

  • Mount Carmel East Hospital

    Columbus, Ohio, 43213, United States

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

  • North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

    Yakima, Washington, 98902, United States

  • NorthShore University HealthSystem-Evanston Hospital

    Evanston, Illinois, 60201, United States

  • NorthShore University HealthSystem-Glenbrook Hospital

    Glenview, Illinois, 60026, United States

  • NorthShore University HealthSystem-Highland Park Hospital

    Highland Park, Illinois, 60035, United States

  • Ochsner Baptist Medical Center

    New Orleans, Louisiana, 70115, United States

  • Ochsner Medical Center Jefferson

    New Orleans, Louisiana, 70121, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • OhioHealth Mansfield Hospital

    Mansfield, Ohio, 44903, United States

  • OhioHealth Pickerington Methodist Hospital

    Pickerington, Ohio, 43147, United States

  • OhioHealth Westerville Medical Campus/Westerville Cancer Center

    Westerville, Ohio, 43082, United States

  • OptumCare Cancer Care at Charleston

    Las Vegas, Nevada, 89102, United States

  • OptumCare Cancer Care at Fort Apache

    Las Vegas, Nevada, 89183, United States

  • Oregon Health and Science University

    Portland, Oregon, 97239, United States

  • PCR Oncology

    Arroyo Grande, California, 93420, United States

  • PROncology

    San Juan, 00927, Puerto Rico

  • Paoli Memorial Hospital

    Paoli, Pennsylvania, 19301, United States

  • Park Nicollet Clinic - Saint Louis Park

    Saint Louis Park, Minnesota, 55416, United States

  • Parkland Health Center - Farmington

    Farmington, Missouri, 63640, United States

  • Pennsylvania Hospital

    Philadelphia, Pennsylvania, 19107, United States

  • Pocono Medical Center

    East Stroudsburg, Pennsylvania, 18301, United States

  • Presbyterian Intercommunity Hospital

    Whittier, California, 90602, United States

  • Providence Newberg Medical Center

    Newberg, Oregon, 97132, United States

  • Providence Portland Medical Center

    Portland, Oregon, 97213, United States

  • Providence Regional Cancer System-Lacey

    Lacey, Washington, 98503, United States

  • Providence Saint Mary Regional Cancer Center

    Walla Walla, Washington, 99362, United States

  • Providence Saint Vincent Medical Center

    Portland, Oregon, 97225, United States

  • Providence Willamette Falls Medical Center

    Oregon City, Oregon, 97045, United States

  • Puerto Rico Hematology Oncology Group

    Bayamón, 00961, Puerto Rico

  • Queen's Cancer Cenrer - POB I

    Honolulu, Hawaii, 96813, United States

  • Queen's Cancer Center - Kuakini

    Honolulu, Hawaii, 96817, United States

  • Queen's Medical Center

    Honolulu, Hawaii, 96813, United States

  • Rapid City Regional Hospital

    Rapid City, South Dakota, 57701, United States

  • Regions Hospital

    Saint Paul, Minnesota, 55101, United States

  • Riddle Memorial Hospital

    Media, Pennsylvania, 19063, United States

  • Riverside Methodist Hospital

    Columbus, Ohio, 43214, United States

  • Roswell Park Cancer Institute

    Buffalo, New York, 14263, United States

  • Rutgers Cancer Institute of New Jersey

    New Brunswick, New Jersey, 08903, United States

  • Saint Alphonsus Cancer Care Center-Boise

    Boise, Idaho, 83706, United States

  • Saint Alphonsus Cancer Care Center-Caldwell

    Caldwell, Idaho, 83605, United States

  • Saint Alphonsus Cancer Care Center-Nampa

    Nampa, Idaho, 83687, United States

  • Saint Alphonsus Cancer Care Center-Ontario

    Ontario, Oregon, 97914, United States

  • Saint Ann's Hospital

    Westerville, Ohio, 43081, United States

  • Saint Francis Medical Center

    Cape Girardeau, Missouri, 63703, United States

  • Saint Joseph Hospital - Orange

    Orange, California, 92868, United States

  • Saint Luke's Cancer Institute - Boise

    Boise, Idaho, 83712, United States

  • Saint Luke's Cancer Institute - Fruitland

    Fruitland, Idaho, 83619, United States

  • Saint Luke's Cancer Institute - Meridian

    Meridian, Idaho, 83642, United States

  • Saint Luke's Cancer Institute - Nampa

    Nampa, Idaho, 83687, United States

  • Saint Luke's Cancer Institute - Twin Falls

    Twin Falls, Idaho, 83301, United States

  • Saint Vincent Hospital Cancer Center Green Bay

    Green Bay, Wisconsin, 54301, United States

  • Saint Vincent Hospital Cancer Center at Oconto Falls

    Oconto Falls, Wisconsin, 54154, United States

  • Saint Vincent Hospital Cancer Center at Saint Mary's

    Green Bay, Wisconsin, 54303, United States

  • Saint Vincent Hospital Cancer Center at Sheboygan

    Sheboygan, Wisconsin, 53081, United States

  • Saint Vincent Hospital Cancer Center at Sturgeon Bay

    Sturgeon Bay, Wisconsin, 54235-1495, United States

  • Sainte Genevieve County Memorial Hospital

    Sainte Genevieve, Missouri, 63670, United States

  • Sanford Bismarck Medical Center

    Bismarck, North Dakota, 58501, United States

  • Sanford Broadway Medical Center

    Fargo, North Dakota, 58122, United States

  • Sanford Cancer Center Oncology Clinic

    Sioux Falls, South Dakota, 57104, United States

  • Sanford Roger Maris Cancer Center

    Fargo, North Dakota, 58122, United States

  • Sanford USD Medical Center - Sioux Falls

    Sioux Falls, South Dakota, 57117-5134, United States

  • Sidney Kimmel Cancer Center Washington Township

    Sewell, New Jersey, 08080, United States

  • Southern Illinois University School of Medicine

    Springfield, Illinois, 62702, United States

  • Southern Ohio Medical Center

    Portsmouth, Ohio, 45662, United States

  • Springfield Clinic

    Springfield, Illinois, 62702, United States

  • Springfield Memorial Hospital

    Springfield, Illinois, 62781, United States

  • Springfield Regional Cancer Center

    Springfield, Ohio, 45504, United States

  • Springfield Regional Medical Center

    Springfield, Ohio, 45504, United States

  • Stanford Cancer Institute Palo Alto

    Palo Alto, California, 94304, United States

  • State University of New York Upstate Medical University

    Syracuse, New York, 13210, United States

  • Strecker Cancer Center-Belpre

    Belpre, Ohio, 45714, United States

  • Swedish Cancer Institute-Edmonds

    Edmonds, Washington, 98026, United States

  • Swedish Cancer Institute-Issaquah

    Issaquah, Washington, 98029, United States

  • Swedish Medical Center-First Hill

    Seattle, Washington, 98122, United States

  • The Mark H Zangmeister Center

    Columbus, Ohio, 43219, United States

  • The Queen's Medical Center - West Oahu

    ‘Ewa Beach, Hawaii, 96706, United States

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania, 19107, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Brighton

    Brighton, Michigan, 48114, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Canton

    Canton, Michigan, 48188, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

    Chelsea, Michigan, 48118, United States

  • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

    Ypsilanti, Michigan, 48197, United States

  • Trinity Health Medical Center - Brighton

    Brighton, Michigan, 48114, United States

  • Trinity Health Medical Center - Canton

    Canton, Michigan, 48188, United States

  • Trinity Health Saint Joseph Mercy Hospital Ann Arbor

    Ann Arbor, Michigan, 48106, United States

  • Trinity Health Saint Joseph Mercy Oakland Hospital

    Pontiac, Michigan, 48341, United States

  • Trinity Health Saint Mary Mercy Livonia Hospital

    Livonia, Michigan, 48154, United States

  • Tufts Medical Center

    Boston, Massachusetts, 02111, United States

  • Tufts Medical Center Cancer Center Stoneham

    Stoneham, Massachusetts, 02180, United States

  • UC Comprehensive Cancer Center at Silver Cross

    New Lenox, Illinois, 60451, United States

  • UChicago Medicine Northwest Indiana

    Crown Point, Indiana, 46307, United States

  • UH Seidman Cancer Center at Lake Health Mentor Campus

    Mentor, Ohio, 44060, United States

  • UH Seidman Cancer Center at Saint John Medical Center

    Westlake, Ohio, 44145, United States

  • UH Seidman Cancer Center at UH Avon Health Center

    Avon, Ohio, 44011, United States

  • UHHS-Chagrin Highlands Medical Center

    Beachwood, Ohio, 44122, United States

  • UI Health Care Mission Cancer and Blood - Ankeny Clinic

    Ankeny, Iowa, 50023, United States

  • UI Health Care Mission Cancer and Blood - Des Moines Clinic

    Des Moines, Iowa, 50309, United States

  • UI Health Care Mission Cancer and Blood - Laurel Clinic

    Des Moines, Iowa, 50314, United States

  • UI Health Care Mission Cancer and Blood - Waukee Clinic

    Waukee, Iowa, 50263, United States

  • UI Health Care Mission Cancer and Blood - West Des Moines Clinic

    Clive, Iowa, 50325, United States

  • UM Sylvester Comprehensive Cancer Center at Aventura

    Aventura, Florida, 33180, United States

  • UM Sylvester Comprehensive Cancer Center at Coral Gables

    Coral Gables, Florida, 33146, United States

  • UM Sylvester Comprehensive Cancer Center at Deerfield Beach

    Deerfield Beach, Florida, 33442, United States

  • UM Sylvester Comprehensive Cancer Center at Kendall

    Miami, Florida, 33176, United States

  • UM Sylvester Comprehensive Cancer Center at Plantation

    Plantation, Florida, 33324, United States

  • UPMC Altoona

    Altoona, Pennsylvania, 16601, United States

  • UPMC Cancer Centers - Arnold Palmer Pavilion

    Greensburg, Pennsylvania, 15601, United States

  • UPMC Hillman Cancer Center

    Pittsburgh, Pennsylvania, 15232, United States

  • UPMC Hillman Cancer Center - Monroeville

    Monroeville, Pennsylvania, 15146, United States

  • UPMC Hillman Cancer Center Erie

    Erie, Pennsylvania, 16505, United States

  • UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion

    Mechanicsburg, Pennsylvania, 17050, United States

  • UPMC Western Maryland

    Cumberland, Maryland, 21502, United States

  • UPMC-Magee Womens Hospital

    Pittsburgh, Pennsylvania, 15213, United States

  • UPMC-Passavant Hospital

    Pittsburgh, Pennsylvania, 15237, United States

  • UT MD Anderson - League City

    League City, Texas, 77573, United States

  • UT MD Anderson - Sugar Land

    Sugar Land, Texas, 77478, United States

  • UT MD Anderson - The Woodlands

    Conroe, Texas, 77384, United States

  • UT MD Anderson - West Houston

    Houston, Texas, 77079, United States

  • UT MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • UT Southwestern/Simmons Cancer Center-Dallas

    Dallas, Texas, 75390, United States

  • United Hospital

    Saint Paul, Minnesota, 55102, United States

  • University of Alabama at Birmingham Cancer Center

    Birmingham, Alabama, 35233, United States

  • University of Chicago Comprehensive Cancer Center

    Chicago, Illinois, 60637, United States

  • University of Chicago Medicine-Orland Park

    Orland Park, Illinois, 60462, United States

  • University of Hawaii Cancer Center

    Honolulu, Hawaii, 96813, United States

  • University of Illinois

    Chicago, Illinois, 60612, United States

  • University of Kentucky/Markey Cancer Center

    Lexington, Kentucky, 40536, United States

  • University of Maryland/Greenebaum Cancer Center

    Baltimore, Maryland, 21201, United States

  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    Miami, Florida, 33136, United States

  • University of Miami Sylvester Comprehensive Cancer Center at Sole Mia

    North Miami, Florida, 33181, United States

  • University of Michigan - Brighton Center for Specialty Care

    Brighton, Michigan, 48116, United States

  • University of Michigan Health - Sparrow Lansing

    Lansing, Michigan, 48912, United States

  • University of Michigan Rogel Cancer Center

    Ann Arbor, Michigan, 48109, United States

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico, 87106, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, 73104, United States

  • University of South Alabama Mitchell Cancer Institute

    Mobile, Alabama, 36688, United States

  • University of Virginia Cancer Center

    Charlottesville, Virginia, 22908, United States

  • University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

    Madison, Wisconsin, 53718, United States

  • University of Wisconsin Carbone Cancer Center - University Hospital

    Madison, Wisconsin, 53792, United States

  • Upper Valley Medical Center

    Troy, Ohio, 45373, United States

  • VCU Community Memorial Health Center

    South Hill, Virginia, 23970, United States

  • VCU Massey Cancer Center at Stony Point

    Richmond, Virginia, 23235, United States

  • VCU Massey Comprehensive Cancer Center

    Richmond, Virginia, 23298, United States

  • Valley Medical Center

    Renton, Washington, 98055, United States

  • Vince Lombardi Cancer Clinic - Oshkosh

    Oshkosh, Wisconsin, 54904, United States

  • Vince Lombardi Cancer Clinic-Sheboygan

    Sheboygan, Wisconsin, 53081, United States

  • Vince Lombardi Cancer Clinic-Two Rivers

    Two Rivers, Wisconsin, 54241, United States

  • Virginia Cancer Institute

    Richmond, Virginia, 23229, United States

  • Walter Reed National Military Medical Center

    Bethesda, Maryland, 20889-5600, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • West Virginia University Healthcare

    Morgantown, West Virginia, 26506, United States

  • Women and Infants Hospital

    Providence, Rhode Island, 02905, United States

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