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Knee cartilage patch study halted early

NCT ID NCT04537013

Disease control Sponsor: Geistlich Pharma AG Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a special collagen patch (Chondro-Gide) placed over large knee cartilage injuries could help people recover as well as standard microfracture surgery for smaller injuries. The study planned to enroll 82 people aged 18-55 with knee cartilage damage. However, the study was terminated early, so results are limited.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

82 people

The number who actually took part.

Started

Aug 2020

Finished

Sep 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Signed written informed consent 2. One symptomatic knee with cartilage defect on the medial femoral condyle, lateral femoral condyle, or trochlea, identified MRI or arthroscopy 3. Between 18 and 55 years of age 4. Subject is willing and able to comply with all study procedures, including visits, diagnostic procedures, and the rehabilitation protocol Exclusion Criteria: 1. BMI ≥ 30 kg/m2 2. Symptomatic contralateral knee 3. Diagnosis of radiographic osteoarthritis with Kellgren-Lawrence grade 3 or more 4. Prior surgical treatment of the cartilage using microfracture, mosaicplasty, or autologous chondrocyte implantation (debridement and lavage are acceptable if the procedure was at least 3 months prior to enrollment) 5. Patella dysplasia 6. Chronic inflammatory arthritis or infectious arthritis 7. History of autoimmune disease or immunodeficiency 8. History of connective tissue disease 9. Intra-articular steroid use within the 3 months prior to enrollment 10. Other intra-articular injections (e.g. hyaluronic acid) within 3 months prior to enrollment 11. The patient is currently being treated with radiation, chemotherapy, immunosuppression or systemic steroid therapy with a dose equivalent to more than 5 mg prednisolone 12. Pregnancy or lack of adequate contraceptives if a female of child-bearing potential 13. Enrolled in another study, involved in the study (as a researcher/investigator/sponsor), or relative of someone directly involved in the study 14. Active infection of the index knee 15. Previous diagnosis of osteoporosis as diagnosed by DEXA, bone densitometry or CT scan 16. Any disorder or impairment that would interfere with evaluation of outcomes measures, such as neurological, degenerative muscular, psychiatric, or cognitive conditions 17. History or current substance or alcohol abuse as defined by the DSM-V 18. Any other medical condition that the investigator determines would interfere with the validity of the study 19. Known allergy to porcine collagen 20. Symptom duration greater than 36 months

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Conditions

The condition(s) this trial relates to.

articular cartilage disorder Cartilage Diseases Fractures, Stress Knee Injuries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cartilage disease Cartilage injury Knee discomfort Knee injuries

Contacts and locations

Locations

  • Emory Sports Medicine Complex

    Johns Creek, Georgia, 30097, United States

  • Fraser Orthopaedic Institute

    New Westminster, British Columbia, V3L 0E4, Canada

  • Gelenkzentrum Mittelrhein GmbH

    Mayen, Mayen, 63 D-56727, Germany

  • Hamilton Health Sciences

    Hamilton, Ontario, L8N 3Z5, Canada

  • Orthopaedic Foundation

    Stamford, Connecticut, 06905, United States

  • Orthopädische Chirurgie München

    München, 81369, Germany

  • Regio Kliniken GmbH

    Pinneberg, Schleswig-Holstein, 25421, Germany

  • Sportklinik Ravensburg

    Ravensburg, Germany

  • St. Joseph's Healthcare Hamilton

    Hamilton, Ontario, L8N 4A6, Canada

  • Sunnybrook Research Institute (SRI)

    Toronto, Ontario, M4N 3M5, Canada

  • The MORE Foundation

    Phoenix, Arizona, 85023, United States

  • University Hospital Regensburg

    Regensburg, Germany

  • University of Calgary

    Calgary, CGY, T2N5A1, Canada

  • University of Toronto Orthopaedics

    Toronto, TOR, M5S 1B2, Canada

  • Universitätsklinikum Schleswig Holstein Campus Lübeck

    Lübeck, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.