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Simple ultrasound may predict ventilator weaning failure in ICU patients

NCT ID NCT07343882

Knowledge-focused Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a special ultrasound technique, called VExUS, can predict which ICU patients will have trouble breathing on their own after being on a ventilator. Researchers will scan the veins of 350 patients just before a breathing trial. The goal is to see if signs of fluid congestion can forecast failure, helping doctors intervene earlier. The study is observational and offers no direct benefit to participants, but could improve care for future patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could give doctors a simple, non-invasive tool to predict which patients will struggle to come off a ventilator, potentially reducing ICU stays and complications.
What could go wrong
This is an early observational study, not a treatment trial. It only tests if the ultrasound method can predict failure—it does not test any new therapy. Results may not change practice immediately.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 350 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged \> 18 years. * Admitted to an Intensive Care Unit (ICU). * Requiring invasive mechanical ventilation for more than 48 hours. * Meeting the center's standard criteria to begin weaning and undergo an SBT. Exclusion Criteria: * Inadequate ultrasound window for assessment. * Presence of "do not reintubate" orders. * Patients with a tracheostomy. * Presence of atrial fibrillation. * Diagnosed liver cirrhosis (portal hypertension). * Absence of qualified personnel to perform the ultrasound at the time of the SBT. * Denial of informed consent.

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Conditions

The condition(s) this trial relates to.

pulmonary edema VEXAS syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mechanical ventilation POCUS Pulmonary edema - acute VEXUS Weaning failure

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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More trials for these conditions

Other studies related to the condition(s) this trial covers.