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Oxygen-Guided transfusions could cut unnecessary blood use in ICUs

NCT ID NCT07509203

Knowledge-focused Sponsor: Semmelweis University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether measuring oxygen levels in the blood (ScvO2) can help doctors decide more precisely when to give red blood cell transfusions to critically ill patients with anemia. The goal is to reduce unnecessary transfusions and their complications. Researchers will compare this oxygen-guided approach to the usual method where doctors decide based on their own judgment. The trial plans to enroll 600 ICU patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
central venous saturation (ScvO2) measurement
What this could lead to
If successful, this could lead to a more personalized and safer way to decide when ICU patients need a blood transfusion, reducing unnecessary transfusions and their risks.
What could go wrong
This is an early-stage protocol study (not yet recruiting) with 600 participants. The approach may not prove better than current practice, and results may not apply to all ICU patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 600 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Apr 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient in medical/surgical/trauma ICU * Hemoglobin level between 7g/dl and 9g/dl * Written informed consent by patient or next of kin * Hemodynamically stable: * CRT normal * Serum lactate \<2 mmol/l * MAP \>65 mmHg * noradrenalin \< 0,2 mcg/kg/min and no increase in 6 hours * No new ischemic change on ECG * Monitored with CVC, arterial catheter, hourly urine output * Respiratorily stable * No support or * Nasal canula/face mask O2 supplementation or * NIV or * Invasive mechanical ventillation: PC/VC/PS, PEEP\< 15 cmH2O FiO2 \< 50% and no increase in 6 hours * PiCCO or expert ECHO available within 48hours Exclusion Criteria: * ScvO2\>80% * Acid-base imbalance (pH\<7.3 or pH\>7.5) * Chronic kidney disease (KDIGO Stage 3-4-5) * Acute heart failure (ESC 2021 definition) * Pregnancy * Active bleeding * Neurotrauma requiring intracranial pressure monitoring * Morbid obesity BMI \>40 * Horowitz Quotient (paO2/FiO2) \< 200 * Acute and chronic liver failure (Child-Pugh B,C) * Fever

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Conditions

The condition(s) this trial relates to.

anemia Critical Illness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anaemia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • North-Pest Central Hospital- Hungarian Defense Forces Medical Center, Department of Anaesthesiology and Intensive Therapy

    Budapest, 1134, Hungary

  • Semmelweis University, Department of Intensive Therapy

    Budapest, 1082, Hungary

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