Scalp block before brain surgery cuts opioid need, study says
NCT ID NCT07545655
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether giving a numbing shot to the scalp before brain surgery (using a head clamp) can lower the amount of strong painkillers needed, keep blood pressure more stable, and reduce inflammation. About 60 adults having planned brain surgery will take part. The goal is to improve recovery and reduce side effects from pain medications.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Apr 2026
An estimate. Start dates often move.
- Expected to finish
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Mar 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients aged 18 years and older who are scheduled for elective intracranial surgery under general anesthesia with planned skull pin head holder (Mayfield-type) fixation, classified as American Society of Anesthesiologists (ASA) physical status I-III, and who have provided informed consent will be included.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Aged 18 years and older * Scheduled for elective intracranial surgery with skull pin head holder fixation * Classified as American Society of Anesthesiologists (ASA) physical status I-III * Provided written informed consent in the preoperative period Exclusion Criteria: * Allergy to local anesthetics * Coagulopathy or anticoagulant use * Local infection at injection site * Pregnancy or breastfeeding * Chronic opioid use (\>3 months) or chronic pain syndrome * Severe psychiatric disorders affecting pain assessment * Emergency surgery * Active infection or rheumatic disease * Hematological disease or malignancy (active or within 5 years) * Recent use of biological agents, chemotherapy, or corticosteroids (within 30 days) * NSAID use within 24 hours before surgery * Advanced organ failure (NYHA III-IV, Child-Pugh C, eGFR \<30 mL/min) * Refusal to participate * Communication difficulties preventing pain assessment
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Fatih Sultan Mehmet Training and Research Hospital
Istanbul, ataşehir, 34752, Turkey (Türkiye)
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