New combo therapy shows promise against hard-to-treat kidney cancer

NCT ID NCT05043090

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen May 23, 2026 · Last updated May 23, 2026

Summary

This study tests whether a combination of two drugs, savolitinib and durvalumab, works better than the standard drug sunitinib for people with a rare type of kidney cancer called papillary renal cell carcinoma that has spread. The cancer must have a specific genetic change (MET-driven). About 148 adults who have not had prior treatment will take part. The main goal is to see if the combination slows cancer growth and helps people live longer.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

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Boston, Massachusetts, 02215, United States
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New York, New York, 10065, United States
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CABA, C1426ANZ, Argentina
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Ciudad Autónoma Buenos Aires, 1125, Argentina
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Ciudad de Buenos Aires, C1120AAT, Argentina
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Ciudad de Buenos Aires, C1181ACH, Argentina
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La Plata, 1900, Argentina
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Rosario, S2002KDS, Argentina
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San Miguel de Tucumán, T4000IAK, Argentina
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Box Hill, 3128, Australia
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Macquarie University, 2109, Australia
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Belo Horizonte, 30120-320, Brazil
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Brasília, 70200-730, Brazil
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Cachoeiro de Itapemirim, 29308-065, Brazil
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Criciúma, 88811-508, Brazil
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Curitiba, 81520-060, Brazil
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Florianópolis, 88020-210, Brazil
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Fortaleza, 60130-241, Brazil
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Natal, 59075-740, Brazil
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Pelotas, 96020-080, Brazil
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Porto Alegre, 90020-090, Brazil
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Porto Alegre, 90110-270, Brazil
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Rio de Janeiro, 22250-905, Brazil
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Salvador, 40050-410, Brazil
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São Jose Do Rio Preto, 15090-000, Brazil
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São Paulo, 01246-000, Brazil
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São Paulo, 01327-001, Brazil
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São Paulo, 05652-900, Brazil
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Vitória, 29043-260, Brazil
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Calgary, Alberta, T2N 4N2, Canada
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Montreal, Quebec, H3T 1E2, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Providencia, 7510032, Chile
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Santiago, 7500653, Chile
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Santiago, 8420383, Chile
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Temuco, 4810561, Chile
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Beijing, 100039, China
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Changsha, 410011, China
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Changsha, 410013, China
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Chongqing, 400030, China
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Harbin, 150049, China
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Jinan, 250012, China
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Nanjing, 210029, China
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Shanghai, 200032, China
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Shenyang, 110042, China
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Tianjin, 300060, China
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Zhengzhou, 450008, China
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Brno, 625 00, Czechia
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Hradec Králové, 500 05, Czechia
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Olomouc, 775 20, Czechia
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Prague, 100 34, Czechia
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Prague, 140 59, Czechia
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Prague, 15000, Czechia
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Prague, 180 81, Czechia
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Bordeaux, 33075, France
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Quimper, 29107, France
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Toulouse, 31059, France
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Villejuif, 94800, France
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Hamburg, 20246, Germany
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Hanover, 30625, Germany
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München, 81377, Germany
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Ulm, 89081, Germany
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Hong Kong, Hong Kong
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Shatin, 00000, Hong Kong
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Bangalore, 560027, India
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Belagavi, 590010, India
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Jaipur, 302002, India
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Mysore, 570001, India
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Nashik, 422004, India
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Haifa, 91096, Israel
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Petah Tikva, 49100, Israel
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Arezzo, 52100, Italy
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Avellino, 83100, Italy
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Bari, 70124, Italy
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Bologna, 40138, Italy
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Florence, 50134, Italy
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Meldola, 47014, Italy
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Milan, 20132, Italy
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Naples, 80131, Italy
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Padova, 35128, Italy
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Reggio Emilia, 42123, Italy
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Tricase, 73039, Italy
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Verona, 37134, Italy
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Aguascalientes, 20230, Mexico
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Monterrey, 64460, Mexico
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Querétaro, 76090, Mexico
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Toluca, 50090, Mexico
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Amsterdam, 1105 AZ, Netherlands
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Arnhem, 6815 AD, Netherlands
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Rotterdam, 3045 PM, Netherlands
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Gdansk, 80-952, Poland
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Gdynia, 81-519, Poland
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Krakow, 30-348, Poland
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Otwock, 05-400, Poland
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Poznan, 60-569, Poland
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Cluj-Napoca, 400015, Romania
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Cluj-Napoca, 400641, Romania
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Craiova, 200094, Romania
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Singapore, 169610, Singapore
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Daejeon, 35015, South Korea
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Goyang-si, 10408, South Korea
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Incheon, 405-760, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06351, South Korea
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A Coruña, 15006, Spain
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Barcelona, 08035, Spain
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Barcelona, 08036, Spain
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Barcelona, ?08041, Spain
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Córdoba, 14004, Spain
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Madrid, 28034, Spain
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Madrid, 28040, Spain
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Madrid, 28041, Spain
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Majadahonda, 28222, Spain
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Málaga, 29010, Spain
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Pamplona, 31008, Spain
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Seville, 41013, Spain
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Valencia, 46026, Spain
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Kaohsiung City, 83301, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 704, Taiwan
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Adana, 01120, Turkey (Türkiye)
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Ankara, 06100, Turkey (Türkiye)
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Ankara, 06200, Turkey (Türkiye)
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Ankara, 06590, Turkey (Türkiye)
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Cordaleo, 35575, Turkey (Türkiye)
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Edirne, 22030, Turkey (Türkiye)
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Istanbul, 32098, Turkey (Türkiye)
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Istanbul, 34218, Turkey (Türkiye)
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Istanbul, 34722, Turkey (Türkiye)
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Izmir, 35040, Turkey (Türkiye)
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Kazımkarabekir, 01230, Turkey (Türkiye)
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Dnipropetrovsk, 49005, Ukraine
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Leicester, LE1 5WW, United Kingdom
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London, EC1A 7BE, United Kingdom
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London, SW3 6JJ, United Kingdom

Conditions

Explore the condition pages connected to this study.

PAPILLARY RENAL CELL CARCINOMA