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Saliva secrets: do clear aligners or braces change your Mouth's chemistry?

NCT ID NCT07397871

Knowledge-focused Sponsor: Riyadh Elm University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 10, 2026 · Updated 2 times

Summary

This study will compare how clear aligners (like Invisalign) and traditional braces change saliva flow, acidity, and buffering capacity in 40 adults. Participants will be randomly assigned to one of the two treatments, and saliva samples will be collected at several points during treatment. The goal is to understand if one method is gentler on oral health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help orthodontists understand how different treatments affect oral health, potentially leading to better care during teeth straightening.
What could go wrong
This is a small, early-stage study (40 participants) measuring saliva changes, not health outcomes. Results may not apply to everyone and won't directly improve treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Class I, II and III skeletal malocclusion. * Age ≥18 undergoing fixed or Clear aligner orthodontic treatment. Exclusion Criteria: * Current medications including antibiotic use within the past 3 months that affect salivary flow and composition. * Active smoking including vaping and E-cigarette use. * Diagnosis of systemic diseases/conditions such as Sjogren's syndrome, diabetes, chronic kidney diseases, neurological conditions. * Active dental caries or signs of gingivitis and/or periodontitis * Less than three months of orthodontic treatment since it is characterized by acute, temporary changes and patient adaptation to the new appliances. * Requiring single arch treatment to standardize the research and eliminate a potential confounding variable * Crown restoration is excluded due to their material properties which may affect salivary composition. * Pregnancy due to the physiological variation in salivary flow and composition due to hormonal changes. * Presence of mouth breathing may lead to inconsistent salivary flow rate, Changes in Salivary Composition and pH * Poor oral hygiene with high levels of dental plaque, calculus, and gingival inflammation can independently alter salivary flow rate, pH, and buffer capacity there by acting as confounding variable.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Orthodontic treatment SALIVA

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Riyadh Elm University

    Riyadh, Saudi Arabia

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