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Saltwater IV may boost exercise in POTS patients

NCT ID NCT01000350

Symptom relief Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a simple IV infusion of saline (salt water) given a few hours before exercise can improve how long and how hard people with postural tachycardia syndrome (POTS) can exercise. Forty adults with POTS will exercise after receiving either saline or a placebo pill, and their peak oxygen use and exercise load will be compared. The goal is to see if this short-term treatment can ease symptoms during exercise.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
saline (salt water)
What this could lead to
If it works, this could point toward a simple way to help people with POTS exercise more comfortably.
What could go wrong
This is a very small, early study with only 40 people. The saline effect may be short-lived or not translate to daily life.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Start date

Oct 2009

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Meet diagnostic criteria of Postural Tachycardia Syndrome (POTS) 28 * Age between 18-65 years * Male and female are eligible (although the majority of POTS patients are female). * Able and willing to provide informed consent Exclusion Criteria: * Presence of medical conditions that can explain postural tachycardia (e.g., acute dehydration, medications) * Pregnancy * Other factors which in the investigator's opinion would prevent the subject from completing the protocol. * Patients who are bedridden or chair-ridden

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Conditions

The condition(s) this trial relates to.

Orthostatic Intolerance postural orthostatic tachycardia syndrome Tachycardia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postural tachycardia syndrome

Contacts and locations

Locations

  • Vanderbilt University

    Nashville, Tennessee, 37232-2195, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.