Good bacteria lozenges aim to fight gum disease and bad breath
NCT ID NCT07508839
First seen Jun 27, 2026 · Last updated Aug 21, 2026 · Updated 2 times
Summary
This study tests whether a probiotic lozenge containing a special strain of Streptococcus salivarius (SALI-10) can reduce gum inflammation and bad breath. Sixty adults with gingivitis will take the lozenge or a placebo twice daily for four weeks. The goal is to see if the probiotic helps control gum disease and improve oral health without the need for ongoing medication.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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May 2026
- Expected to finish
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Apr 2027
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Male or female volunteers aged 18-70 years 2. In good general health, ASA I 3. Non-smokers 4. Fluent in English 5. For sexually active volunteers of childbearing potential, one of the following methods must be used to prevent pregnancy during the study by participants. 1. Post-menopausal 2. hormonal birth control (oral, injectable, transdermal, intra-vaginal) or intrauterine device must be in use at least 30 days prior to first study drug administration; 3. barrier methods must be in use at least 14 days prior to study drug administration; 4. that vasectomy on the male partner must be completed 3 months prior to first study drug administration; 5. or in the alternative that a 0 sperm count for the male partner will suffice Exclusion Criteria: 1. Presence of orthodontic bands. 2. Presence of partial removal dentures. 3. Dental pain at time of screening. 4. History of allergy to a consumer or personal care products or dentifrice ingredients as determined by the dental profession monitoring the study, or to any of the following: sorbitol, isomalt, dibasic calcium phosphate, potato or potato starch, mint or mint flavour, glyceryl dibehenate, steviol glycosides. 5. Participation in any other clinical study or test panel within one month before entering the study. 6. Current use of anti-inflammatory, antibiotics, or antimicrobial drugs or within the last 30 days of enrolment. 7. Those taking anticoagulant medications and have blood and bleeding disorders 8. Those who have recently experienced (past 30 days) or will be experiencing (next 90 days) dental, oral, or any type of surgery 9. History of systemic inflammatory or immune conditions or immunocompromised conditions 10. Pregnant or nursing women or those planning on getting pregnant. 11. Use of tobacco products. 12. Long-term antibiotic or anti-inflammatory therapy. 13. Medical condition or any current usage of medication that the investigator considers may compromise the subject's safety as well as the quality of the study results (note, only Advil and Tylenol are allowed during the study for analgesia) 14. Medication or Natural Health Products (NHPs) that could affect the gingiva like calcium channel blockers, anti-epileptic therapy etc. 15. Participants who are experiencing nausea, fever, vomiting, bloody diarrhoea or severe abdominal pain. 16. Presence of active infections 17. Use of any probiotic 18. Use of anti-plaque/anti-gingivitis products 19. Subjects who must receive dental treatment during the study elates 20. Concurrent orthodontic treatment 21. Untreated carious lesions and/or inadequate restorations on maxillary posterior teeth 22. Periodontal disease (periodontal pockets, probing depth (PD) \< 3.0 mm on at least one tooth/site, presence of Clinical Attachment Loss (CAL) = 0 mm, or periodontal disease history)
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Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The study's own enquiry address
This study publishes an address for enquiries. See it below .
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
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Contacts and locations
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Genom att skicka in godkänner du våra Användarvillkor
Locations
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OMGPerio
RECRUITINGHamilton, Ontario, L8N 1K4, Canada
Contact Email: •••••@•••••
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