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Saffron supplement shows promise for menopause symptoms

NCT ID NCT06227858

Symptom relief Sponsor: Liaquat University of Medical & Health Sciences Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether a daily saffron extract supplement can reduce common perimenopause symptoms like mood changes, sleep problems, and hot flashes in healthy women over 40. 104 women with irregular periods and moderate-to-severe symptoms took either saffron or a placebo for several weeks. The goal was to see if saffron could improve their quality of life without the need for hormones or antidepressants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

104 people

The number who actually took part.

Started

Aug 2025

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 55 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Biological Female which identify themselves as Women * Aged ≥ 40 years * Irregular menstrual cycle for at least 3 months * Presenting typical symptoms of perimenopause with GCS score over 20 * BMI range between 18-35 kg/m2 * Healthy woman Exclusion Criteria: * Less than 40 years old * Pregnant * Diagnosed with diseases related to reproductive system such as PCOS or endometriosis * Taking anti-depressant medication or sleeping pills * Taking hormonal replacement therapy (HRT) * Taking conventional drug treatment or dietary supplementation * Having medical history or medical/surgical event in the last 6 months, or has been treated for cancer or any other ongoing treatment for the past 3 months, * Current and/or past history of hyper/hypotension, CVD, diabetes, autoimmune diseases, musculoskeletal disorder or endocrine or immunocompromised or neurological or psychological disorders, * Being medicated for these conditions, * History of allergic reactions to saffron intake, * Decisionally challenged subjects or unable to comply to the study * Any conditions that could contraindicates the use of saffron * Currently smoking or ceased smoking in the past 3 months

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Perimenopausal disorder

Contacts and locations

Locations

  • Department of Biochemistry, LUMHS

    Jāmshoro, Sindh, 76060, Pakistan

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