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Can HIIT and protein shots boost metabolism in midlife women?

NCT ID NCT06098183

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study looked at how high-intensity interval training (HIIT) and protein drinks affect metabolism in overweight women going through perimenopause. Researchers measured energy use and fat burning before and after exercise in 28 women. The goal was to understand how muscle and fat changes during this life stage impact metabolic health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Whey protein isolate
What this could lead to
If successful, this study could point toward better exercise and nutrition strategies to support metabolic health during perimenopause.
What could go wrong
This is a small, completed observational study with only 28 participants, so results may not apply broadly. It does not test a treatment or cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

28 people

The number who actually took part.

Started

Mar 2024

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

38 to 60 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Early and late perimenopausal women (≥38 years; early: experienced menstrual bleeding in the previous 3 months with a decrease in cycle regularity in the past year; late: no menstrual bleeding in the previous 3 months with some bleeding in the previous year). * Overweight and obese: body mass index (BMI) of 28 - 40 Kg/m\^2 and percent body fat (%BF) ≥ 30%. * Healthy, non-smokers. Exclusion Criteria: * Have current and/or history of cardiovascular disease, diabetes, metabolic, thyroid, pulmonary, renal, hepatic, gastrointestinal, musculoskeletal disorders or medical or surgical events, such as bariatric surgery, heart surgery, or any joint or musculoskeletal injuries or surgeries occurring in the 6-months prior to enrollment, that may significantly influence study outcomes or prevent safe participation. * Gained or lost \>5 kg in the previous 2 months * Have a self-identified or clinically diagnosed eating disorder * Undergone a full or partial hysterectomy for treatment of menopausal symptoms * Have uncontrolled hypertension or an abnormal electrocardiogram. * Have an ongoing diagnosed mental disorder with a change in medication in the previous 6 months. * Taking metabolism-altering drugs or medications outside of estrogen replacement therapy that may influence study outcomes (i.e. corticosteroids, stimulants, insulin, thyroid medications) or phytoestrogens. * Diagnosed with polycystic ovarian syndrome (PCOS). * Participating in more than 75 minutes per week of moderate exercise per week. * Currently pregnant or planning to become pregnant (determined from urine pregnancy test) * Currently nursing or have had a child within the previous 6 months * Has participated in another clinical trial within four weeks prior to enrollment that in the opinion of the PI would influence the results. * Has severely impaired hearing or speech or inability to speak English. * Unwilling or unable to comply with the study protocol, including abstaining from caffeine, tobacco, alcohol, and physical activity before testing days.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Applied Physiology Laboratory - University of North Carolina

    Chapel Hill, North Carolina, 27599, United States

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