Can HIIT and protein shots boost metabolism in midlife women?
NCT ID NCT06098183
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study looked at how high-intensity interval training (HIIT) and protein drinks affect metabolism in overweight women going through perimenopause. Researchers measured energy use and fat burning before and after exercise in 28 women. The goal was to understand how muscle and fat changes during this life stage impact metabolic health.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Whey protein isolate
- What this could lead to
- If successful, this study could point toward better exercise and nutrition strategies to support metabolic health during perimenopause.
- What could go wrong
- This is a small, completed observational study with only 28 participants, so results may not apply broadly. It does not test a treatment or cure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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28 people
The number who actually took part.
- Started
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Mar 2024
- Finished
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Aug 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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38 to 60 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Early and late perimenopausal women (≥38 years; early: experienced menstrual bleeding in the previous 3 months with a decrease in cycle regularity in the past year; late: no menstrual bleeding in the previous 3 months with some bleeding in the previous year). * Overweight and obese: body mass index (BMI) of 28 - 40 Kg/m\^2 and percent body fat (%BF) ≥ 30%. * Healthy, non-smokers. Exclusion Criteria: * Have current and/or history of cardiovascular disease, diabetes, metabolic, thyroid, pulmonary, renal, hepatic, gastrointestinal, musculoskeletal disorders or medical or surgical events, such as bariatric surgery, heart surgery, or any joint or musculoskeletal injuries or surgeries occurring in the 6-months prior to enrollment, that may significantly influence study outcomes or prevent safe participation. * Gained or lost \>5 kg in the previous 2 months * Have a self-identified or clinically diagnosed eating disorder * Undergone a full or partial hysterectomy for treatment of menopausal symptoms * Have uncontrolled hypertension or an abnormal electrocardiogram. * Have an ongoing diagnosed mental disorder with a change in medication in the previous 6 months. * Taking metabolism-altering drugs or medications outside of estrogen replacement therapy that may influence study outcomes (i.e. corticosteroids, stimulants, insulin, thyroid medications) or phytoestrogens. * Diagnosed with polycystic ovarian syndrome (PCOS). * Participating in more than 75 minutes per week of moderate exercise per week. * Currently pregnant or planning to become pregnant (determined from urine pregnancy test) * Currently nursing or have had a child within the previous 6 months * Has participated in another clinical trial within four weeks prior to enrollment that in the opinion of the PI would influence the results. * Has severely impaired hearing or speech or inability to speak English. * Unwilling or unable to comply with the study protocol, including abstaining from caffeine, tobacco, alcohol, and physical activity before testing days.
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Applied Physiology Laboratory - University of North Carolina
Chapel Hill, North Carolina, 27599, United States
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Other studies related to the condition(s) this trial covers.
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