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Pre-Pregnancy health linked to child development in major singapore study

NCT ID NCT03531658

Knowledge-focused Sponsor: KK Women's and Children's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows over 1,000 women in Singapore from before pregnancy through their child's early years. Researchers are looking at how nutrition, lifestyle, and emotional health before and during early pregnancy may influence the child's body composition, brain development, and long-term health. The goal is to uncover early factors that shape a child's future well-being.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help identify key factors before pregnancy that influence a child's metabolic and brain health, guiding future preventive strategies.
What could go wrong
This is an observational study, not a treatment trial. It cannot prove cause and effect, and results may take years to translate into practical advice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

1,054 people

The number who actually took part.

Started

Feb 2015

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Healthy women aged between 18 and 35 who are actively planning to conceive within a 1-year time frame upon recruitment, and later along with their children born from the indexed pregnancy.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria of Mother Participants: 1. Women aged 18-35 years 2. Intention to reside in Singapore for the next 5 years 3. Chinese, Malay, Indian or any combinations of these 3 ethnic groups 4. Planning to conceive within 1 year 5. Able to provide written, informed consent Exclusion Criteria of Mother Participants: 1. Have been actively trying to conceive for more than 18 months 2. Currently pregnant 3. Assisted fertility, apart from those taking clomiphene alone in the past 1 month 4. Established pre-existing diabetes (type 1 or type 2) 5. Oral or implanted contraception, or with an IUCD in situ in the past 1 month 6. On systemic steroids in the past 1 month 7. On anticonvulsants in the past 1 month 8. On HIV or Hepatitis B or C medication in the past 1 month 9. Not becoming pregnant after more than 12 months from recruitment 10. Eventual multiple pregnancies 11. Pregnancy complications such as miscarriages, ectopic pregnancy, still birth The partners of the women will also be invited to participate in the study. Babies born from these mothers will be followed up until the child is 9 years of age.

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Conditions

The condition(s) this trial relates to.

Developmental Origins of Health and Disease inherited disease susceptibility metabolic disease Neurologic Manifestations skin disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Environmental exposure Genetics predisposition Metabolic disease Neurological and mental health conditions Psychology, social Skin condition Socioeconomic factors

Contacts and locations

Locations

  • KK Women's and Children's Hospital

    Singapore, Singapore

More trials for these conditions

Other studies related to the condition(s) this trial covers.