Can a Low-Dose anesthetic cut opioid use after hysterectomy?
NCT ID NCT02543385
First seen Aug 14, 2026 · Last updated Aug 14, 2026
Summary
This trial tests whether giving a low dose of S-ketamine during anesthesia can reduce the need for morphine and its side effects in women undergoing open abdominal hysterectomy for benign conditions. Half the participants receive S-ketamine, while the other half receive a placebo, and the study compares their morphine use over the first 24 hours after surgery. The goal is to see if this approach can make pain management safer and more comfortable.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- S-ketamine (a low-dose anesthetic drug given intravenously during surgery)
- What this could lead to
- If effective, this could offer a way to reduce opioid use and related side effects after abdominal hysterectomy, potentially improving recovery.
- What could go wrong
- This is a small, early-stage trial, and results may not apply to all patients. S-ketamine can have side effects like nausea or dizziness, and its benefit over placebo is not yet proven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Start date
-
Jun 2014
- Finished
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Jun 2015
- Lead sponsor
-
A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
21 to 80 years
- Sex
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Female participants only
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Females above the age of 21 years old scheduled undergoing open abdominal hysterectomy with remifentanil-propofol TCI in KKH for benign condition (fibroids, adenomyosis), * Be willing and able to give written informed consent for participation in this study * ASA I/II patient's. Exclusion Criteria: * Patient with contraindications to the use of S+ketamine, as listed in the product label e.g. untreated or insufficiently treated thyroid hyperfunction, unstable angina pectoris or myocardial infarction within the last 6 months, diseases of the CNS, increased intraocular pressure and perforating ocular injuries, surgical procedures in the upper respiratory tract, etc * Patients with a h/o drug or alcohol abuse * Regular use of analgesics, or use of opioids within 12 hours of surgery * Patient on chronic use of benzodiazepine or neurololeptics * Patient on thyroid replacement hormone * H/o IHD,HTN,Thyroid disorder. * BMI\> 30kg/m2. * H/o Psychiatric disorder. * Laproscopic surgery converted to open surgery. * Pregnant or breast feeding female's.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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