Which painkiller wins after hysterectomy? a Head-to-Head test
NCT ID NCT06837506
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial compares two ways to manage pain after an open total abdominal hysterectomy: an ultrasound-guided rectus sheath block (a numbing injection into the abdominal wall) versus intrathecal morphine (a spinal injection). About 80 women aged 18-65 will be randomly assigned to one of the two methods. The goal is to see which approach provides better pain relief, reduces the need for extra morphine, and has fewer side effects.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Ultrasound-guided rectus sheath block with bupivacaine 0.25% versus intrathecal morphine
- What this could lead to
- If one method proves superior, it could become the preferred standard for managing pain after open hysterectomy, potentially reducing opioid use and side effects.
- What could go wrong
- This is a small, single-center trial, so results may not apply broadly. Both methods carry risks like infection, bleeding, or allergic reactions, and pain relief may vary between individuals.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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80 people
The number who actually took part.
- Started
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Feb 2025
- Finished
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Dec 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age: 18 - 65 years old. * American Society of Anesthesiologists (ASA) physical status (I -II). * Patients undergoing open total abdominal hysterectomy. Exclusion Criteria: * Hepatic, renal, or cardiac disease. * Any known allergy to local anesthetic. * Physical or mental conditions which may vague measuring postoperative pain following surgery. * History of chronic use of analgesic as nonsteroidal anti-inflammatory drugs (NSAIDs) or central nervous system (CNS) depressants as antiepileptic, and bleeding disorders.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ain Shams University
Cairo, 11591, Egypt
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