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Brain zaps + arm training: new hope for stroke survivors?

NCT ID NCT06752499

Symptom relief Sponsor: Ruijin Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether combining repetitive transcranial magnetic stimulation (rTMS) with motor training helps stroke patients regain arm function. 60 participants were split into three groups: online rTMS during training, offline rTMS before training, or sham stimulation. They received 10 sessions over two weeks. The goal was to see if online rTMS boosts recovery more than the other approaches.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
repetitive transcranial magnetic stimulation (rTMS)
What this could lead to
If it works, this could point toward a better way to help stroke survivors regain arm movement.
What could go wrong
This is a small, early-stage study with only 60 people. Results may not apply to all stroke patients, and the improvement might be small.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Feb 2023

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. The patient is first diagnosed with stroke through neurological examination, CT or MRI scan. 2. The vital signs are stable and there is a certain degree of upper limb motor dysfunction. 3. The age is between 20 and 80 years old. 4. The cognitive ability is not significantly affected and the patient can cooperate with various examinations and assessments, with a MMSE score ≥ 20 points. 5. There are no serious complications (such as pneumonia, heart failure, urinary tract infection or malnutrition). 6. There is no pathological condition that is a contraindication for TMS in the medical history (for example, patients with metal in the brain, such as aneurysm clips, patients with a cardiac pacemaker, pregnant women, or those with a history of epileptic seizures). 7. The patient or guardian agrees to sign the informed consent form. Exclusion Criteria: 1. Patients with severe heart, lung, liver, kidney diseases and malignant tumors; 2. Those with a history of aphasia, severe cognitive impairment or mental illness; 3. Patients who have had a history of epileptic seizures in the last month or are taking anti-epileptic drugs recently; 4. Those with severe visual or hearing impairments, unable to communicate normally; 5. People with metal implants, pacemakers, skull defects or other conditions that prevent them from undergoing TMS.

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Conditions

The condition(s) this trial relates to.

Paresis stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Stroke Upper extremity paresis

Contacts and locations

Locations

  • Changhai Hospital

    Shanghai, Yangpu, China

  • Shanghai Ruijin Hospital, affiliated to Shanghai Jiao Tong University, School of medicine

    Shanghai, Shanghai Municipality, 200025, China

  • Shanghai Yang Zhi Rehabilitation Hospital

    Shanghai, Songjiang, China

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