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Can magnetic pulses boost memory in dementia?

NCT ID NCT02621424

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study tested whether repetitive transcranial magnetic stimulation (rTMS) can improve memory and thinking in 32 veterans aged 55+ with mild cognitive impairment or dementia. Participants received either real rTMS or a sham (fake) treatment. The main goal was to see changes in verbal memory scores right after treatment and again 4 months later.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
repetitive transcranial magnetic stimulation (rTMS)
What this could lead to
If it works, this could point toward a non-drug way to ease memory problems in people with early dementia.
What could go wrong
This was a very small, early study with only 32 participants. Results may not apply to everyone, and any memory benefits might be small or short-lived.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

32 people

The number who actually took part.

Started

Jan 2016

Finished

Sep 2025

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

55 to 99 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Veterans aged 55 years or older * Diagnosed with Mild Cognitive Impairment (MCI) or dementia likely due to Alzheimer's disease. * Ability to obtain a Motor Threshold, determined during the screening process. * With an adequately stable condition and living environment to enable attendance at scheduled clinic visits. * If on a prescription medication for cognition that medication dose will be stable for at least 4 weeks prior to randomization into the study and participant will be willing to remain on a stable regimen during the acute treatment phase. * Able to read, verbalize understanding, and voluntarily sign the Informed Consent Form to be signed by the participant, or a designated legal representative when the participant lacks decision making capacity prior to participating in any study- specific procedures or assessments. Exclusion Criteria: * Patients with prior exposure to rTMS or electroconvulsive therapy (ECT). * Unable to safely withdraw, at least two weeks prior to treatment commencement, from medications that substantially increase the risk of having seizures. * Have a cardiac pacemaker or a cochlear implant. * Have an implanted device deep brain stimulation or metal in the brain * Current substance abuse not including caffeine or nicotine as determined by patient report or chart review. * Active current suicidal intent or plan as determined by patient report or chart review. * Current or Prior history of a seizure disorder as determined by patient report or chart review * Traumatic brain injury within the last two months * Participation in another concurrent interventional clinical trial * Known current psychosis as determined by patient report or chart review. * Current or prior history of a mass lesion, cerebral infarct or other non-cognitive, active central nervous system (CNS) disease that would increase the risk for seizure. * Not fluent in English or a hearing impairment severe enough to impair comprehension

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Cognitive Dysfunction dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • VA Palo Alto Health Care System, Palo Alto, CA

    Palo Alto, California, 94304-1207, United States

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