Can magnetic pulses boost memory in dementia?
NCT ID NCT02621424
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed study tested whether repetitive transcranial magnetic stimulation (rTMS) can improve memory and thinking in 32 veterans aged 55+ with mild cognitive impairment or dementia. Participants received either real rTMS or a sham (fake) treatment. The main goal was to see changes in verbal memory scores right after treatment and again 4 months later.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- repetitive transcranial magnetic stimulation (rTMS)
- What this could lead to
- If it works, this could point toward a non-drug way to ease memory problems in people with early dementia.
- What could go wrong
- This was a very small, early study with only 32 participants. Results may not apply to everyone, and any memory benefits might be small or short-lived.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
32 people
The number who actually took part.
- Started
-
Jan 2016
- Finished
-
Sep 2025
- Lead sponsor
-
A government agency
The lead sponsor is a US federal agency other than the NIH.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
55 to 99 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Veterans aged 55 years or older * Diagnosed with Mild Cognitive Impairment (MCI) or dementia likely due to Alzheimer's disease. * Ability to obtain a Motor Threshold, determined during the screening process. * With an adequately stable condition and living environment to enable attendance at scheduled clinic visits. * If on a prescription medication for cognition that medication dose will be stable for at least 4 weeks prior to randomization into the study and participant will be willing to remain on a stable regimen during the acute treatment phase. * Able to read, verbalize understanding, and voluntarily sign the Informed Consent Form to be signed by the participant, or a designated legal representative when the participant lacks decision making capacity prior to participating in any study- specific procedures or assessments. Exclusion Criteria: * Patients with prior exposure to rTMS or electroconvulsive therapy (ECT). * Unable to safely withdraw, at least two weeks prior to treatment commencement, from medications that substantially increase the risk of having seizures. * Have a cardiac pacemaker or a cochlear implant. * Have an implanted device deep brain stimulation or metal in the brain * Current substance abuse not including caffeine or nicotine as determined by patient report or chart review. * Active current suicidal intent or plan as determined by patient report or chart review. * Current or Prior history of a seizure disorder as determined by patient report or chart review * Traumatic brain injury within the last two months * Participation in another concurrent interventional clinical trial * Known current psychosis as determined by patient report or chart review. * Current or prior history of a mass lesion, cerebral infarct or other non-cognitive, active central nervous system (CNS) disease that would increase the risk for seizure. * Not fluent in English or a hearing impairment severe enough to impair comprehension
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
VA Palo Alto Health Care System, Palo Alto, CA
Palo Alto, California, 94304-1207, United States
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