New MS drug copycat aims to match ocrevus in early trial
NCT ID NCT07597668
First seen May 20, 2026 · Last updated Jun 19, 2026 · Updated 6 times
Summary
This Phase 1 trial compares a new drug called RPH-035 to the approved MS drug Ocrevus. The study involves 180 adults with relapsing-remitting or secondary progressive multiple sclerosis who have flare-ups. Researchers are checking if RPH-035 behaves similarly in the body and has a comparable safety profile to Ocrevus.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Federal State Budgetary Educational Institution of Higher Education "Siberian State Medical University" of the Ministry of Health of the Russian Federation
Tomsk, 634050, Russia
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Federal State Budgetary Healthcare Institution "Siberian District Medical Center of the Federal Medical and Biological Agency"
Novosibirsk, 630007, Russia
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Federal State Budgetary Institution Federal Siberian Scientific and Clinical Center of the Federal Medical and Biological Agency
Krasnoyarsk, 660037, Russia
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Federal State Budgetary Scientific Institution "Russian Center for Neurology and Neurosciences"
Moscow, 125367, Russia
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Joint Stock Company "Medical and Sanitary Unit "Neftyanik"
Tyumen, 625048, Russia
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Kazan State Medical Academy, branch of the Federal State Budgetary Educational Institution of Additional Professional Education Russian Medical Academy of Continuing Professional Education
Kazan', 420061, Russia
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Kirov Regional State Clinical Budgetary Healthcare Institution "Center for Cardiology and Neurology"
Kirov, 610007, Russia
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LLC "Center for Diagnostics and Rehabilitation "PRAKSIMED"
Saint Petersburg, 194223, Russia
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Limited Liability Company DOCKBRAIN
Krasnodar, 350049, Russia
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MEDIS Limited Liability Company
Nizhny Novgorod, 603137, Russia
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Research Lab LLC
Moscow, 127521, Russia
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Rostov Regional Clinical Hospital, State Budgetary Institution of the Rostov Region
Rostov-on-Don, 344015, Russia
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Smolensk Regional Clinical Hospital, Regional State Budgetary Healthcare Institution
Smolensk, 214018, Russia
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St. Petersburg State Budgetary Healthcare Institution "City Clinical Hospital No. 31"
Saint Petersburg, 197110, Russia
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State Autonomous Healthcare Institution "Interregional Clinical and Diagnostic Center"
Kazan', 420101, Russia
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State Autonomous Healthcare Institution Regional Clinical Hospital No. 3
Chelyabinsk, 454021, Russia
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State Budgetary Healthcare Institution Leningrad Regional Clinical Hospital
Saint Petersburg, 194291, Russia
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State Budgetary Healthcare Institution of the City of Moscow "City Clinical Hospital No. 24 of the Moscow Health Department"
Moscow, 127015, Russia
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State Budgetary Healthcare Institution of the Nizhny Novgorod Region "Nizhny Novgorod Regional Clinical Hospital named after N. A. Semashko"
Nizhny Novgorod, 603126, Russia
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State Budgetary Healthcare Institution of the Novosibirsk Region "State Novosibirsk Regional Clinical Hospital"
Novosibirsk, 630087, Russia
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State Budgetary Healthcare Institution of the Perm Region "Perm Regional Clinical Hospital of the Order of the Badge of Honor"
Perm, 614045, Russia
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State Budgetary Healthcare Institution of the Republic of Mordovia "Republican Clinical Hospital No. 4"
Saransk, 430032, Russia
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Ulyanovsk Regional Clinical Hospital, a public health institution
Ulyanovsk, 432017, Russia
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ocrelizumab (RPH-035 and Ocrevus)
What this could lead to
If successful, this could show that RPH-035 is a safe and effective alternative to Ocrevus for managing multiple sclerosis.
What could go wrong
This is an early Phase 1 study focused on comparing drug levels and safety, not on proving effectiveness. It is small and may not lead to a new treatment option.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.