Does a Real-Time tissue check during lung biopsy boost genetic testing success?
NCT ID NCT04945317
First seen Jan 04, 2026 · Last updated Jun 22, 2026 · Updated 26 times
Summary
This study compares two ways of doing a lung biopsy (EBUS) for people with known or suspected non-small cell lung cancer. In one group, a cytotechnologist checks the tissue sample on-site during the procedure to give feedback. In the other group, no on-site check is done. The goal is to see if on-site evaluation leads to more successful genetic testing from the biopsy tissue. About 349 participants will be enrolled at Johns Hopkins and other sites.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Johns Hopkins Bayview Medical Center
Baltimore, Maryland, 21224, United States
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Johns Hopkins Hospital
Baltimore, Maryland, 21287, United States
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Northwestern Medicine
Chicago, Illinois, 60611, United States
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The Medical University of South Carolina (MUSC)
Charleston, South Carolina, 29425, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Rapid on-site cytopathologic evaluation (ROSE) during bronchoscopy
What this could lead to
If successful, this could show that having a cytotechnologist on-site during bronchoscopy improves the chance of getting enough tissue for genetic testing, guiding better treatment choices for lung cancer patients.
What could go wrong
This is a procedural comparison, not a new drug or therapy. Even if ROSE improves tissue collection, it may not change patient outcomes or survival. The study is observational in nature and results may not apply to all hospitals.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.