Does a Real-Time tissue check during lung biopsy boost genetic testing success?

NCT ID NCT04945317

ENROLLING_BY_INVITATION Knowledge-focused Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two ways of doing a lung biopsy (EBUS) for people with known or suspected non-small cell lung cancer. In one group, a cytotechnologist checks the tissue sample on-site during the procedure to give feedback. In the other group, no on-site check is done. The goal is to see if on-site evaluation leads to more successful genetic testing from the biopsy tissue. About 349 participants will be enrolled at Johns Hopkins and other sites.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Rapid on-site cytopathologic evaluation (ROSE) during bronchoscopy
What this could lead to: If successful, this could show that having a cytotechnologist on-site during bronchoscopy improves the chance of getting enough tissue for genetic testing, guiding better treatment choices for lung cancer patients.
What could go wrong: This is a procedural comparison, not a new drug or therapy. Even if ROSE improves tissue collection, it may not change patient outcomes or survival. The study is observational in nature and results may not apply to all hospitals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER (NSCLC)

Contacts and locations

Locations

Johns Hopkins Bayview Medical Center

Baltimore, Maryland, 21224, United States
Johns Hopkins Hospital

Baltimore, Maryland, 21287, United States
Northwestern Medicine

Chicago, Illinois, 60611, United States
The Medical University of South Carolina (MUSC)

Charleston, South Carolina, 29425, United States

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