New hope for cirrhosis patients: drug may prevent brain fog after liver procedure

NCT ID NCT02016196

Completed Prevention Sponsor: University Hospital, Toulouse Source: ClinicalTrials.gov ↗

First seen May 08, 2026 · Last updated May 23, 2026 · Updated 3 times

Summary

This study tested whether the drug rifaximin can prevent a serious brain condition called hepatic encephalopathy in people with cirrhosis who undergo a TIPS procedure. TIPS helps reduce pressure in the liver but often leads to brain complications. The trial involved 211 participants and compared rifaximin to a placebo to see if it could reduce the risk of this brain problem.

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Contacts and locations

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Locations

CHRU Lille

Lille, France
CHU Angers

Angers, France
CHU Beaujon Clichy

Paris, France
CHU Bordeaux

Bordeaux, France
CHU Marseille

Marseille, France
CHU Nantes

Nantes, France
CHU Poitiers

Poitiers, France
CHU Rennes

Rennes, France
CHU Saint-Antoine

Paris, France
CHU Tours

Tours, France
Hôpital Jean Verdier

Bondy, France
Pitié Salpêtrière

Paris, France
UHToulouse

Toulouse, France, 31059, France

Conditions

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CIRRHOSIS