New hope for young leukemia patients: experimental drug combo enters human testing
NCT ID NCT03740334
First seen Nov 21, 2025 · Last updated Jun 18, 2026 · Updated 28 times
Summary
This early-phase study tests a new three-drug combination (ribociclib, everolimus, and dexamethasone) in children and young adults up to age 30 whose acute lymphoblastic leukemia has returned or not responded to standard treatments. The main goals are to find the safest dose and understand how the body processes the drugs. About 45 participants will be enrolled to see if the combination can control the disease.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Boston Children's Hospital
Boston, Massachusetts, 02115, United States
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Children's Healthcare of Atlanta
Atlanta, Georgia, 30322, United States
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Children's Hospital of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10174, United States
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Nemours/Alfred I. duPont Hospital for Children
Wilmington, Delaware, 19803, United States
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Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
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Texas Children's Hospital
Houston, Texas, 77030, United States
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.