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Breaking the loop: could stopping rumination lower blood pressure and depression?

NCT ID NCT05980130

Symptom relief Sponsor: University of Louisville Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This small study tested a type of talk therapy called Rumination-Focused Cognitive Behavior Therapy (RFCBT) in 9 low-income adults who had both depressive symptoms and high blood pressure. The therapy aims to help people recognize and stop repetitive negative thoughts (rumination), which may contribute to both depression and heart disease. Researchers measured changes in rumination, depressive symptoms, and blood pressure to see if the therapy could improve both mental and heart health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Rumination-Focused Cognitive Behavior Therapy (RFCBT)
What this could lead to
If it works, this therapy could offer a way to lower both depression and heart disease risk by breaking the cycle of repetitive negative thinking.
What could go wrong
This is a very small proof-of-concept study with only 9 participants and no control group. Results may not apply to the general population.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

9 people

The number who actually took part.

Started

Aug 2023

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * RSQ-Brooding score: \>= 11 * PHQ-9 score: 10-20 * SBP: \>= 120 and/or DBP: \>= 80) * fluent in English Exclusion Criteria: * None besides the described inclusion criteria

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Conditions

The condition(s) this trial relates to.

Depression hypertensive disorder rumination disorder Rumination Syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Blood pressure Depressive symptoms Rumination

Contacts and locations

Locations

  • Have a Heart clinic

    Louisville, Kentucky, 40202, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.