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Heat therapy may shrink thyroid lumps without surgery

NCT ID NCT07237373

Symptom relief Sponsor: University Hospital, Ghent Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Aug 27, 2026 · Updated 3 times

Summary

This study looks at whether radiofrequency ablation (RFA) can safely reduce symptoms and improve quality of life in adults with benign thyroid nodules. Fifty participants will undergo the procedure and be followed for one year. The goal is to see if this minimally invasive heat treatment can shrink nodules and relieve pressure or appearance issues.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
radiofrequency ablation (RFA) device
What this could lead to
If it works, this could offer a non-surgical option to shrink thyroid nodules and ease discomfort or cosmetic concerns.
What could go wrong
This is a small, early observational study with only 50 participants. Results may not apply to everyone, and risks like pain, voice changes, or incomplete shrinkage are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Apr 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Study participants will be selected from the following Belgian hospitals: Ghent University Hospital, University Hospital Leuven, AZ Sint Jan Brugge.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * \> 18 years old * 'Eastern Cooperative Oncology Group' (ECOG) performance status of 0 or 1 * Symptomatic benign thyroid nodules with compressive/cosmetic complaints OR autonomously functioning thyroid nodules with subclinical hyperthyreosis or thyrotoxicosis proven on scintigraphy. * No cutoff in nodule size. * Solid component \> 20%, and benign cytology (Bethesda II) in 1 (EUTIRADS 3) or 2 (EUTIRADS 4) separate cytological assessments. In the case of a proven "hot" nodule on scintigraphy, no biopsy is required. Exclusion Criteria: * \<18y * Purely cystic nodule * Severe comorbidity which limits the further life expectancy of the patient to \< 2 years (opinion of the physician) * Malignancies \<2 years ago except for non-melanoma skin cancer and non-muscle invasive bladder cancer. * Lack of compliance * Malignant or suspicious thyroid nodules or nodules that are confluent in a compressive lobar mass * Contralateral vocal cord paralysis * Anticoagulant therapy that could not be suspended * Unresolvable coagulation disorders * Absence of consent of the patient

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Conditions

The condition(s) this trial relates to.

benign thyroid gland neoplasm toxic thyroid adenoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Benign thyroid nodule

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AZ Sint-Jan Brugge

    RECRUITING

    Bruges, 8000, Belgium

  • UZ Gent

    RECRUITING

    Ghent, 9000, Belgium

  • UZ Leuven

    RECRUITING

    Leuven, 3000, Belgium

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