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New study: could a daily supplement and strength training beat menopause blues?

NCT ID NCT07135232

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether a plant-based supplement (sarmentosin and L-theanine) combined with home strength training can improve mood, sleep, and muscle health in women going through perimenopause. 72 women aged 40-55 will be split into four groups: supplement plus exercise, supplement only, placebo plus exercise, or placebo only. They will take capsules daily and some will do resistance exercises three times a week for 12 weeks, with regular check-ups on symptoms and cognition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Sarmentosin and L-theanine supplement
What this could lead to
If it works, this could offer a non-hormonal option to help manage perimenopausal symptoms and maintain muscle strength.
What could go wrong
This is a small, early-stage trial with 72 participants, so results may not apply to everyone. The supplement is new and its long-term effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 72 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 55 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria 1. Perimenopausal women between 40 - 55 years 2. Not currently engaging in consistent structured resistance training (defined as \>3 resistance training sessions per week for 4 consecutive weeks, in the past six months). 3. Not on any HRT or hormonal contraception for at least one year before initiation of the study. 4. Able to attend laboratory visits and commit to the intervention schedule for 6 months. 5. Willing to provide blood samples 6. Not regularly consuming any dietary supplements containing concentrated sarmentosin, L-theanine or other compounds that may interfere with the study intervention. 7. Willing to limit dietary intake of Sarmentosin (e.g. Blackcurrant) and L-theanine (e.g. green tea/ black tea). 8. Willing and able to provide written informed consent Exclusion criteria 1. Diagnosed cardiovascular disease (CVD), uncontrolled hypertension (\>160/100 mmHg), or other conditions that prevent safe exercise participation. 2. Clinically diagnosed mental health disorders (e.g., bipolar disorder, schizophrenia, severe depression requiring medication adjustment within the last 6 months). 3. Neurological conditions affecting cognitive function (e.g., Parkinson's disease, multiple sclerosis, epilepsy). 4. Endocrine disorders that could impact hormonal fluctuations or metabolism (e.g., uncontrolled diabetes, thyroid dysfunction). 5. History of major musculoskeletal injuries (e.g., fractures, joint replacement) within the past 6 months 6. Regular use of medications that could interfere with study outcomes, including antidepressants, corticosteroids, beta-blockers. 7. Obesity (BMI \>30 or for South Asian Ethinicity BMI\> 27.5) 8. Food allergy or intolerance to study products. 9. Use of illicit drugs. 10. Alcohol intake exceeding the government guidelines of 14 standard units per week (Equivalent of 6 standard drinks). 11. Pregnant or planning to conceive during the trial. 12. High habitual caffeine intake (\>400 mg/day which is approximately 4-5 cups of coffee)

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Conditions

The condition(s) this trial relates to.

anxiety disorder Depression Hot Flashes Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Carnegie School of Sport

    RECRUITING

    Leeds, North Humberside, LS2 3AE, United Kingdom

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