New study: could a daily supplement and strength training beat menopause blues?
NCT ID NCT07135232
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether a plant-based supplement (sarmentosin and L-theanine) combined with home strength training can improve mood, sleep, and muscle health in women going through perimenopause. 72 women aged 40-55 will be split into four groups: supplement plus exercise, supplement only, placebo plus exercise, or placebo only. They will take capsules daily and some will do resistance exercises three times a week for 12 weeks, with regular check-ups on symptoms and cognition.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Sarmentosin and L-theanine supplement
- What this could lead to
- If it works, this could offer a non-hormonal option to help manage perimenopausal symptoms and maintain muscle strength.
- What could go wrong
- This is a small, early-stage trial with 72 participants, so results may not apply to everyone. The supplement is new and its long-term effects are unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 72 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Mar 2026
An estimate. Start dates often move.
- Expected to finish
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Apr 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 55 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria 1. Perimenopausal women between 40 - 55 years 2. Not currently engaging in consistent structured resistance training (defined as \>3 resistance training sessions per week for 4 consecutive weeks, in the past six months). 3. Not on any HRT or hormonal contraception for at least one year before initiation of the study. 4. Able to attend laboratory visits and commit to the intervention schedule for 6 months. 5. Willing to provide blood samples 6. Not regularly consuming any dietary supplements containing concentrated sarmentosin, L-theanine or other compounds that may interfere with the study intervention. 7. Willing to limit dietary intake of Sarmentosin (e.g. Blackcurrant) and L-theanine (e.g. green tea/ black tea). 8. Willing and able to provide written informed consent Exclusion criteria 1. Diagnosed cardiovascular disease (CVD), uncontrolled hypertension (\>160/100 mmHg), or other conditions that prevent safe exercise participation. 2. Clinically diagnosed mental health disorders (e.g., bipolar disorder, schizophrenia, severe depression requiring medication adjustment within the last 6 months). 3. Neurological conditions affecting cognitive function (e.g., Parkinson's disease, multiple sclerosis, epilepsy). 4. Endocrine disorders that could impact hormonal fluctuations or metabolism (e.g., uncontrolled diabetes, thyroid dysfunction). 5. History of major musculoskeletal injuries (e.g., fractures, joint replacement) within the past 6 months 6. Regular use of medications that could interfere with study outcomes, including antidepressants, corticosteroids, beta-blockers. 7. Obesity (BMI \>30 or for South Asian Ethinicity BMI\> 27.5) 8. Food allergy or intolerance to study products. 9. Use of illicit drugs. 10. Alcohol intake exceeding the government guidelines of 14 standard units per week (Equivalent of 6 standard drinks). 11. Pregnant or planning to conceive during the trial. 12. High habitual caffeine intake (\>400 mg/day which is approximately 4-5 cups of coffee)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Carnegie School of Sport
RECRUITINGLeeds, North Humberside, LS2 3AE, United Kingdom
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Other studies related to the condition(s) this trial covers.
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- Can Omega-3s keep menopausal minds sharp?
- Does hormone therapy for menopause leave a mark on breasts and arteries?
- A phone game takes on menopause brain fog
- Can faith help women navigate menopause? a study looks for answers