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New drug cocktail shows promise for tough liver cancers

NCT ID NCT05194293

First seen Oct 31, 2025 · Last updated Apr 30, 2026 · Updated 31 times

Summary

This early-phase trial tests whether combining regorafenib (a targeted therapy) with durvalumab (an immunotherapy) can shrink tumors in 4 adults with high-risk liver cancer before surgery. The goal is to see if the treatment reduces tumor size enough to improve surgical outcomes. Participants must have stage IB to IIIA liver cancer and be healthy enough for surgery.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Emory University Hospital/Winship Cancer Institute

    Atlanta, Georgia, 30322, United States

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • University of Alabama at Birmingham Cancer Center

    Birmingham, Alabama, 35233, United States

Conditions

Explore the condition pages connected to this study.