New drug combo shows promise in shrinking High-Risk liver tumors

NCT ID NCT05194293

First seen Oct 31, 2025 · Last updated Jun 13, 2026 · Updated 39 times

Summary

This phase 2 trial tests whether combining regorafenib (a drug that blocks cancer cell growth) with durvalumab (an immunotherapy that helps the immune system attack cancer) can shrink tumors in people with high-risk liver cancer. The study includes 4 adults with early-stage liver cancer who are eligible for surgery. The goal is to see if this treatment can reduce tumor size and improve surgical outcomes.

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Contacts and locations

Locations

  • Emory University Hospital/Winship Cancer Institute

    Atlanta, Georgia, 30322, United States

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • University of Alabama at Birmingham Cancer Center

    Birmingham, Alabama, 35233, United States

Conditions

Explore the condition pages connected to this study.