New mesh could save failing dental implants
NCT ID NCT06153212
First seen Jun 24, 2026 · Last updated Sep 02, 2026 · Updated 4 times
Summary
This study tests a new reinforced PTFE mesh (RPM) against a standard collagen membrane for treating peri-implantitis, a gum infection around dental implants. Thirty-two adults with at least one infected implant will receive surgery to clean the implant, fill the bone defect with graft, and cover it with one of the two membranes. The goal is to see which material better restores bone and gum health around the implant.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- reinforced PTFE mesh (RPM) and collagen membrane with bone grafting
- What this could lead to
- If successful, this could provide a better surgical option to treat gum disease around dental implants, potentially saving implants that might otherwise be lost.
- What could go wrong
- This is a small early-stage trial with only 32 participants, so results may not apply to everyone. The new mesh might not heal better than the standard collagen membrane, and surgery carries risks like infection or implant failure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 32 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2023
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥ 18 years * Physical status according to the American Society of Anesthesiology (ASA) I or II, which include patients who are systematically healthy or may suffer from mild to moderate, however well-controlled systemic diseases. * Subjects having at least one dental implant with peri-implantitis according to the definition proposed by the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions (Berglundh et al., 2018): * Full-mouth plaque score and full-mouth bleeding score ≤ 20% (measured at four sites per tooth) * Correct 3-dimensional implant positioning, or buccal position ≤ 1 mm * Implants which have been in function for at least 6 months Exclusion Criteria: * A clearly mal-positioned dental implant * Significant interproximal horizontal bone loss (more than 50% of implant fixture length) * A mobile dental implant * Presence of uncontrolled or untreated periodontal disease * More than 2 weeks usage of antibiotics in the past two months * Subjects taking medications known to modify bone metabolism or those that can interfere with the normal wound healing (such as bisphosphonates, corticosteroids, hormone replacement therapy, parathyroid hormone, denosumab, strontium ranelate, etc.), or those with uncontrolled systemic diseases or conditions that may similarly affect the patient's healing (osteoporosis, osteopenia, hyperparathyroidism, Paget's disease, uncontrolled diabetes (HBA1c \> 8)). * Pregnant subjects or individuals attempting to get pregnant (self-reported) * Subjects smoking more than 10 cigarettes a day, or those with a history of drug or alcohol abuse (self-reported) * Subjects unable to maintain adequate oral hygiene (O'Leary plaque index more than 50%) (O'Leary et al., 1972) * Any other contraindications for undergoing periodontal surgery
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of Michigan School of Dentistry
Ann Arbor, Michigan, 48109, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can Air-Polishing save ailing dental implants?
- Could tiny metal shavings from dental implants fuel gum disease?
- Could your bone health decide if a dental implant lasts?