Can nicotine lozenges and E-Cigs protect kids from secondhand smoke?
NCT ID NCT01935713
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether giving nicotine lozenges, e-cigarettes, or dissolvable tobacco lozenges to caregivers who smoke could reduce the amount of secondhand smoke their children are exposed to. The 89 participating caregivers were not interested in quitting smoking but were willing to try these products. Researchers measured changes in children's saliva cotinine levels to track exposure.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Nicotine replacement products (lozenges, e-cigarettes, dissolvable tobacco lozenges)
- What this could lead to
- If successful, this could offer a way for caregivers who are not ready to quit smoking to reduce their children's exposure to secondhand smoke.
- What could go wrong
- This is a small, early-stage study (89 participants) with no control group, so results may not be generalizable. The products themselves contain nicotine, which has its own health risks.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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89 people
The number who actually took part.
- Start date
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Apr 2012
- Finished
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Dec 2012
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: In order to be included in the study, participants must: 1. be the primary caregiver(defined as a person who spends the most time with the child and spends a minimum of 4 hours per day in the presence of the child) of a child between the ages of 3-11 (if caregiver has more \> 1 child between 3-11 years, we will include the youngest) 2. smoke at least 10 cigarettes per day for the past year 3. indicate that they smoke around their child or in the car or home at least one time per week\] 4. have no intention of quitting smoking in the next 12-weeks 5. aged 18-65 years 6. be fluent in English 7. have no recent history of cardiovascular distress that may contraindicate medicinal nicotine lozenge use (heart attack in the past year, arrhythmia, uncontrolled hypertension) 8. not currently pregnant, planning to become pregnant, or breastfeeding 9. do not use non-cigarette tobacco (cigars, chewing tobacco) 10. have no prior use of any potential reduced exposure product 11. have no major psychiatric impairment, including psychosis, suicidality, and/or any current alcohol/drug abuse or dependence Exclusion Criteria: * Does not meet all of the requirements of inclusion criteria
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The Children's Hospital at OU Medical Center
Oklahoma City, Oklahoma, 73104, United States
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