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Study reveals hidden lung damage from secondhand smoke in flight attendants

NCT ID NCT02797275

Knowledge-focused Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how long-term exposure to secondhand tobacco smoke changes the lungs of never-smoking flight attendants who worked on planes before smoking was banned. Researchers want to see if a bronchodilator, a medicine that opens airways, can help with breathing problems found in this group. The study involves 107 participants and uses exercise tests to measure lung function.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

107 people

The number who actually took part.

Started

Jun 2016

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Never Smoking SHS-exposed Flight Attendants: * aircraft cabin SHS exposure of \>1 year while working for airlines * Never smoker as defined by use of \<100 cigarettes lifetime and none within the last year. * Normal forced expiratory volume (FEV) FEV1/ forced vital capacity (FVC) ratio * One of the following evidence of airflow obstruction: * Presence of any airflow limitation on spirometry during the baseline visit * Development of airflow limitation on spirometry during any stages of exercise testing * Residual volume to total lung capacity ratio of \>0.35 2. Exclusion Criteria: * History of active cardiac disease, uncontrolled hypertension, congestive heart failure * History of direct tobacco use of over 100 cigarettes in their lifetime * History of established respiratory diseases such as asthma, emphysema, chronic bronchitis, interstitial lung disease, or sarcoidosis * History of debilitating chronic illnesses such as severe lupus or rheumatoid arthritis * History of other illnesses or therapy for illnesses that could affect lung function such as radiation therapy for breast cancer * Physical inability to perform exercise testing * BMI \>30 kg/m2 * History of marijuana use of \>100 joints lifetime, and none within the last year * History of other recreational drug use

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Conditions

The condition(s) this trial relates to.

nicotine dependence obstructive lung disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Air trapping Airflow limitation Hyperinflation Obstructive lung disease Secondhand smoke Tobacco

Contacts and locations

Locations

  • University of California San Francisco

    San Francisco, California, 94143, United States

  • VA Medical Center

    San Francisco, California, 94121, United States

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