New pain block could cut opioid use after gynecologic surgery
NCT ID NCT06575699
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 34 times
Summary
This study tested whether a rectus sheath block (a type of nerve block) using liposomal bupivacaine can reduce the need for opioid painkillers after gynecologic cancer surgery. Thirty patients received the block and were compared to 60 similar patients who had epidural pain relief. The main goal was to measure opioid use in the first 72 hours after surgery.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Duke University Medical Center
Durham, North Carolina, 27710, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
liposomal bupivacaine and bupivacaine hydrochloride
What this could lead to
If successful, this approach could offer a simpler, effective pain control method after gynecologic cancer surgery, potentially reducing opioid use and side effects.
What could go wrong
This is a small pilot study with only 30 participants receiving the block, compared to historical controls. Results may not apply to all patients, and the block may not be as effective as epidural analgesia.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.