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Knee surgery pain study: could rebound pain predict months of suffering?

NCT ID NCT07511985

Knowledge-focused Sponsor: Konya City Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Aug 21, 2026 · Updated 4 times

Summary

This study will follow 220 adults having knee replacement surgery to see if a short burst of pain after a nerve block (called rebound pain) is linked to chronic pain that lasts for months. Participants will keep pain diaries and answer surveys at 3 and 6 months after surgery. No new treatments are being tested—the goal is simply to understand the connection.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors predict and prevent chronic pain after knee replacement by managing rebound pain better.
What could go wrong
This is an observational study, not a treatment trial. It only looks for a link, so it won't prove that preventing rebound pain stops chronic pain. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 220 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients undergoing unilateral elective total knee arthroplasty at Konya City Hospital under spinal anesthesia and receiving a peripheral nerve block as part of routine multimodal analgesia.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older * ASA physical status I to III * Scheduled for unilateral elective total knee arthroplasty * Planned to undergo spinal anesthesia * Planned to receive a peripheral nerve block as part of routine multimodal analgesia * Able to provide informed consent and complete study assessments Exclusion Criteria: * Chronic opioid use (60 mg oral morphine equivalent per day or more, or use for 3 months or longer) * Significant neuropathy or radiculopathy * Bilateral or two-stage total knee arthroplasty during the same hospitalization * Contralateral total knee arthroplasty within the previous 6 months * Severe cognitive impairment or major psychiatric disorder * Chronic analgesic dependence

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute pain, postoperative Arthroplasty, replacement, knee Chronic pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Mahmut TUTAR

    RECRUITING

    Konya, Meram, Turkey (Türkiye)

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