New exercise approach aims to realign knees and ease pain
NCT ID NCT07410429
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study compares a standard physical therapy program with a targeted exercise program designed to improve knee alignment in adults aged 30-55 with mild to moderate knee osteoarthritis and bow-legged alignment. About 80 participants will do either standard exercises or specific hip and leg exercises for 6 weeks, with follow-ups up to one year. The goal is to see if the targeted approach better reduces pain and improves function.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- targeted alignment-focused exercise program
- What this could lead to
- If it works, this could point toward a more effective exercise approach for reducing knee pain and slowing osteoarthritis progression in people with bow-legged alignment.
- What could go wrong
- This is a small, early-stage trial with only 80 participants, so results may not apply to everyone. The exercises are supervised for only 6 weeks, and long-term benefits are uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
About 80 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Oct 2025
- Expected to finish
-
Oct 2026
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
30 to 55 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
* Inclusion Criteria * Age 30-55 years * BMI 18-25 kg/m² * Presence of medial knee pain * Mild to moderate varus deformity confirmed via long-leg X-ray (e.g., 2° \< Hip-Knee-Ankle angle ≤ 10°) * Kellgren-Lawrence grade 1-3 knee osteoarthritis * Active adults based on REFA work classification * Able and willing to complete a 6-week exercise program and follow-up visits * Provision of written informed consent * Exclusion Criteria: * BMI \> 25 kg/m² * History of knee surgery on the affected side * Any contraindication to exercise (e.g., unstable cardiovascular conditions) * Other significant musculoskeletal or neurological conditions affecting lower-extremity function (e.g., hip osteoarthritis, rheumatoid arthritis, peripheral neuropathy)
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Knee osteoarthritis (kellgren-lawrence grade 1-3) are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Faculty of Medicine, Assiut University
Asyut, Asyut Governorate, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.