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Collagen vs. glucosamine: which supplement eases knee pain?

NCT ID NCT07746466

Disease control Sponsor: Liaquat National Hospital & Medical College Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 05, 2026 · Last updated Aug 11, 2026 · Updated 3 times

Summary

This trial tests whether a daily bioactive collagen peptide supplement can improve knee pain, stiffness, and physical function in adults with mild to moderate knee osteoarthritis. Participants are randomly assigned to take either the collagen supplement or a glucosamine and chondroitin combination for 12 weeks. The study measures changes in symptoms and quality of life using standard questionnaires, and tracks any side effects. The goal is to see if collagen peptide is a safe and effective non-surgical option for managing knee osteoarthritis.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Bioactive collagen peptide (fish collagen with Curcuma longa extract) compared with glucosamine and chondroitin sulphate
What this could lead to
If it works, this could offer a simpler, non-surgical option for managing mild to moderate knee osteoarthritis symptoms.
What could go wrong
This is a 12-week trial with 150 participants, so results may not apply broadly. Supplements can cause side effects, and the collagen may not prove better than the standard combination.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

150 people

The number who actually took part.

Started

Jun 2023

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 40 years and older. * Clinical diagnosis of knee osteoarthritis according to the American College of Rheumatology (ACR) criteria. * Radiographic Kellgren-Lawrence grade I, II, or III osteoarthritis in at least one knee. * Willing and able to provide written informed consent. * Willing to comply with the study protocol and attend all follow-up visits. Exclusion Criteria: * Inflammatory arthritis, including rheumatoid arthritis, systemic lupus erythematosus, spondyloarthropathy, or polymyalgia rheumatica. * Post-traumatic osteoarthritis. * Patients with hyperuricemia. * Pregnancy or breastfeeding. * Previous use of collagen peptide or glucosamine-chondroitin supplements before enrollment. * Inability or unwillingness to comply with study procedures or complete follow-up.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis (kellgren-lawrence grade 1-3)

Contacts and locations

Locations

  • Liaquat National Hospital and Medical College

    Karachi, Sindh, 74800, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.