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10,000 patients enrolled in global study to find best heart disease treatment

NCT ID NCT01341327

Knowledge-focused Sponsor: Seung-Jung Park Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is observing 10,000 people with severe narrowing in the left main coronary artery, a critical heart vessel. Researchers are comparing the long-term results of three approaches: medication, stenting with drug-coated stents, and bypass surgery. The goal is to see which works best in everyday medical practice, not just in controlled trials.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors choose the best treatment for left main coronary artery disease based on real-world evidence.
What could go wrong
This is an observational study, not a controlled trial, so results may be influenced by factors like patient choice or doctor preference. It does not test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 10,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2007

Expected to finish

Dec 2033

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Consecutive patients with unprotected LMCA diseases at participating centers will be evaluated for the entry into the study.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Significant unprotected left main stenosis (\>50% by visual estimation) * The LMCA is considered unprotected if there are no patent coronary artery bypass grafts to the left anterior descending artery or the left circumflex artery. * No limitation of clinical or lesion characteristics * Age \>18 years * The patient or guardian agrees to the study protocol and the schedule of clinical follow-up, and provides informed, written consent, as approved by the appropriate Institutional Review Board/Ethics Committee of the respective clinical site. Exclusion Criteria: * Protected left main stenosis

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Conditions

The condition(s) this trial relates to.

coronary artery disorder coronary stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Coronary artery disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    28 sites in 5 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ajou University Hospital

    TERMINATED

    Suwon, South Korea

  • Asan Medical Center

    RECRUITING

    Seoul, 138-736, South Korea

  • Bundang CHA Hospital

    TERMINATED

    Seongnam, South Korea

  • Chonbuk National University Hospital

    RECRUITING

    Jeonju, South Korea

  • Chonnam National University Hospital

    RECRUITING

    Gwangju, South Korea

  • Chungnam National University Hospital

    RECRUITING

    Daejeon, South Korea

  • Daegu Catholic University Medical Center

    RECRUITING

    Daegu, South Korea

  • Dongguk University Medical Center

    RECRUITING

    Seoul, South Korea

  • Gangnam Severance Hospital

    RECRUITING

    Seoul, South Korea

  • Gangneung Asan Medical Center

    RECRUITING

    Gangneung, South Korea

  • Hallym University medical center

    RECRUITING

    Anyang, South Korea

  • Inje University Busan Paik Hospital

    RECRUITING

    Busan, South Korea

  • Kangbuk samsung hospital

    RECRUITING

    Seoul, South Korea

  • Kangdong Sacred Heart Hospital

    RECRUITING

    Seoul, South Korea

  • Keimyung University Dongsan Medical Center

    RECRUITING

    Daegu, South Korea

  • Korea University Anam hospital

    RECRUITING

    Seoul, South Korea

  • Korea University Guro Hospital

    RECRUITING

    Seoul, South Korea

  • Kwangju Christian hospital

    RECRUITING

    Kwangju, South Korea

  • National Health Insurance Service Ilsan Hospital

    TERMINATED

    Ilsan, South Korea

  • Presbyterian Medical Center

    RECRUITING

    Jeonju, South Korea

  • Pusan Natioanal University Hospital

    RECRUITING

    Pusan, South Korea

  • Sarawak General Hospital

    RECRUITING

    Kuching, Malaysia

  • Seoul National University Boramae Medical Center

    RECRUITING

    Seoul, South Korea

  • Seoul National University Hospital

    RECRUITING

    Seoul, South Korea

  • Seoul Veterans Hospital

    TERMINATED

    Seoul, South Korea

  • Shin Kong Hospital

    RECRUITING

    Taipei, Taiwan

  • Siriraj Hospital

    RECRUITING

    Bangkok, Thailand

  • Soonchunhyang University Hospital, Buchen

    TERMINATED

    Bucheon-si, South Korea

  • Soonchunhyang University Hospital, Cheonan

    RECRUITING

    Cheonan, South Korea

  • St.Mary's Catholic Medical Center

    TERMINATED

    Cheongju-si, South Korea

  • St.Mary's Catholic Medical Center

    TERMINATED

    Inchon, South Korea

  • St.Mary's Catholic Medical Center

    TERMINATED

    Seoul, South Korea

  • The Catholic University of Korea, Bucheon ST.Mary's Hospital

    TERMINATED

    Bucheon-si, South Korea

  • The Catholic University of Korea, Daejeon ST.Mary's Hospital

    TERMINATED

    Daejeon, South Korea

  • The Catholic University of Korea, ST. Paul's Hospital

    TERMINATED

    Seoul, South Korea

  • The Catholic University of Korea, ST. Vincent's Hospital

    RECRUITING

    Suwon, South Korea

  • The Catholic University of Korea, Yeouido ST. Mary's Hospital

    TERMINATED

    Seoul, South Korea

  • Ulsan University Hospital

    RECRUITING

    Ulsan, South Korea

  • Wonju Christian Hospital

    RECRUITING

    Wŏnju, South Korea

  • Yeungnam University Medical Center

    TERMINATED

    Daegu, South Korea

  • Yonsei University Medical Center

    TERMINATED

    Seoul, South Korea

  • Zhongshan Hospital

    RECRUITING

    Shanghai, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.