New cell therapy shows promise for tough scleroderma cases

NCT ID NCT06655896

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 22, 2026 · Updated 29 times

Summary

This study tests a one-time cell therapy called rapcabtagene autoleucel against the standard drug rituximab in 96 people with severe, hard-to-treat scleroderma. The goal is to see if the new treatment can improve skin hardening, lung function, and quality of life better than the current option. Participants must have had symptoms for less than 7 years and meet specific disease criteria.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Avera Cancer
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Sioux Falls, South Dakota, 57105, United States

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Boston Medical Center
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Boston, Massachusetts, 02118, United States

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FL Medical Clinic Orlando Health
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Zephyrhills, Florida, 33542, United States

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James Cancer Hospital
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Columbus, Ohio, 43210, United States

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LDS Hospital
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Salt Lake City, Utah, 84143, United States

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Michigan Med University of Michigan
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Ann Arbor, Michigan, 48109 5271, United States

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Northwestern University
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Chicago, Illinois, 60611, United States

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Novartis Investigative Site
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Camperdown, New South Wales, 2050, Australia
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Darlinghurst, New South Wales, 2010, Australia
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Graz, 8036, Austria
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Vienna, 1090, Austria
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Ghent, 9000, Belgium
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Salvador, Estado de Bahia, 41253-190, Brazil
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Barretos, São Paulo, 14784 400, Brazil
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São Paulo, São Paulo, 01232-010, Brazil
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São Paulo, São Paulo, 01308-050, Brazil
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Olomouc, 779 00, Czechia
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Prague, 128 00, Czechia
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Aarhus N, 8200, Denmark
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Bordeaux, 33076, France
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Dijon, 21000, France
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Lille, 59037, France
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Lyon, 69003, France
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Montpellier, 34295, France
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Paris, 75014, France
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Rennes, 35033, France
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Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
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Göttingen, Lower Saxony, 37075, Germany
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Leipzig, Saxony, 04103, Germany
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Halle, Saxony-Anhalt, 06120, Germany
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Jena, Thuringia, 07740, Germany
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Berlin, 13353, Germany
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Lübeck, 23538, Germany
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Mainz, 55131, Germany
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Nuremberg, 90419, Germany
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Ulm, 89081, Germany
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Debrecen, Hajdu Bihar Megye, 4032, Hungary
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Budapest, H-1083, Hungary
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Haifa, 3109601, Israel
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Ramat Gan, 5265601, Israel
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Tel Aviv, 6423906, Israel
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Ancona, AN, 60126, Italy
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Bergamo, BG, 24127, Italy
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Brescia, BS, 25123, Italy
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Genova, GE, 16132, Italy
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Milan, MI, 20122, Italy
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Milan, MI, 20132, Italy
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Pescara, PE, 65124, Italy
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Perugia, PG, 06129, Italy
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Pisa, PI, 56126, Italy
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Pavia, PV, 27100, Italy
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Roma, RM, 00168, Italy
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Udine, UD, 33100, Italy
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Sapporo, Hokkaido, 060-8648, Japan
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Sendai, Miyagi, 9808574, Japan
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Suita, Osaka, 565-0871, Japan
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Bunkyo-ku, Tokyo, 113-8603, Japan
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Fukuoka, 8128582, Japan
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Ishikawa, 9208641, Japan
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Kyoto, 6068507, Japan
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Utrecht, 3584 CX, Netherlands
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Singapore, 169608, Singapore
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Seoul, 04763, South Korea
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Seoul, 06591, South Korea
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Santiago Compostela, A Coruna, 15706, Spain
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Santander, Cantabria, 39008, Spain
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Pamplona, Navarre, 31008, Spain
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Barcelona, 08035, Spain
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Barcelona, 08041, Spain
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Córdoba, 14004, Spain
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Madrid, 28009, Spain
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Madrid, 28041, Spain
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Málaga, 29010, Spain
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Salamanca, 37007, Spain
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Valencia, 46026, Spain
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Geneva, 1211, Switzerland
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Lausanne, 1011, Switzerland
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Zurich, 8091, Switzerland
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Taichung, 407219, Taiwan
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Sheffield, South Yorkshire, S10 2JF, United Kingdom
Oregon Health Sciences University
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Portland, Oregon, 97239, United States

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Sutter Health Network
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San Pablo, California, 94806, United States

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UCLA
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Los Angeles, California, 90095, United States

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UCSF
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San Francisco, California, 94115, United States
UCSF
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San Francisco, California, 94115, United States

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University Of Iowa
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Iowa City, Iowa, 52242, United States

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University of Minnesota
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Minneapolis, Minnesota, 55455, United States

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Conditions

Explore the condition pages connected to this study.

SCLERODERMA, DIFFUSE