Anti-Aging drug and football drills join forces to fight brittle bones

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Postmenopausal women aged 45-60 years old as evidenced by measuring serum levels of LH and FSH and absence of menstruation for at least 1 year. * No history of low energy hip or vertebral fractures during the last 6 months. * Ability to provide informed consent. Exclusion Criteria: * Diabetes (type 1 and 2) * Heart failure similar to NYHA Class IV * Primary hyperparathyroidism * Known disorders affecting bone metabolism, e.g., uncontrolled thyrotoxicosis, severe renal impairment (eGFR \<20) or liver function (baseline phosphatase higher than twice upper limit (105 U/L)), active rheumatic diseases, celiac disease, severe chronic obstructive lung disease (COPD), hypopituitarism, or Cushing's disease. * Previous use of bone antiresorptive or bone anabolic drugs within the last 5 years. * Use of anabolic steroids in the previous year * Treatment with drugs known to affect cytochrome P450 3A due to its role in everolimus metabolism * History of coagulopathy or medical condition requiring long-term anticoagulation * Anemia - Hg \< 9.0 g/dl, Leukopenia - white blood cells (WBC) \< 3,500/mm3, Neutropenia absolute neutrophil count \< 2,000/mm3, or Platelet count - platelet count \< 125,000/mm3 * Patients with impaired wound healing or history of a chronic open wound * Scheduled for immunosuppressant therapy for transplant or scheduled to undergo chemotherapy or any other treatment for malignancy * Untreated dyslipidemia with LDL-c \> 4.9 mmol/L and family history of dyslipidemia, Total cholesterol \> 9.1 mmol/L, or triglycerides \> 9.9 mmol/L * Any form of clinically relevant primary or secondary immune dysfunction or deficiency * Unstable ischemic heart disease * Bone mineral density (BMD) measured by DXA scanning with T-score \<-3 * Known allergy to rapamycin or rapalogs * The study will exclude participants with inability to speak and understand Danish and with inability to cooperate or perform physical training. * Inability to give informed consent