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Can lung MRI replace CT scans for detecting a serious Post-Transplant lung condition?

NCT ID NCT04080232

Diagnosis Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether lung MRI can diagnose bronchiolitis obliterans syndrome (BOS) after allogeneic stem cell transplant as well as chest CT scans. BOS is a serious lung complication that can occur after transplant, and early diagnosis is important. Researchers compared MRI and CT scans in 16 adult patients to see if MRI could spot the same lung abnormalities. If MRI works well, it could provide a radiation-free option for monitoring these patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, lung MRI could offer a safer, radiation-free way to detect bronchiolitis obliterans syndrome earlier after stem cell transplant.
What could go wrong
This is a small, completed study with only 16 participants, so results may not apply to everyone. MRI may not be as accurate as CT scans for all lung details.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

16 people

The number who actually took part.

Started

Feb 2020

Finished

May 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient ≥ 18 yo ; * Patient who underwent an allogeneic stem cell transplantation (SCT) * \> 3 months post-SCT * With evidence of * respiratory symptoms, and/or * Pathological PFTs defined by : obstructive syndrome (FEV1 :vital capacity/CVF \< 0.7), FEV1 \< 0.75 of pre-SCT values, residual volume \> 120%, and/or ; * Altered PFTs consistent with 0p stage described in lung transplantation BOS: FEV1 decline ≥ 10 % and/or FEF25-75 decline ≥ 25% compared to pre-SCT PFTs, and/or ; * Abnormal chest CT-scan with findings consistent with BOS: evidence of air trapping on expiratory CT-scan, bronchiectasis, and/or airway thickening. Exclusion Criteria: * Contraindication for MRI ; * Contraindication of oxygen administration ; * Decompensation of altered respiratory function ; * Acute respiratory infection (bacterial, fungal or viral) documented in the last 6 weeks ;

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Conditions

The condition(s) this trial relates to.

Bronchiolitis Obliterans bronchiolitis obliterans syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bronchiolitis obliterans

Contacts and locations

Locations

  • CHU Bordeaux

    Bordeaux, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.