Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

New combo therapy targets both psoriasis and obesity in major trial

NCT ID NCT06588283

Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding a weight-loss drug (tirzepatide) to a standard psoriasis treatment (ixekizumab) helps people with moderate-to-severe plaque psoriasis who are also overweight or obese. About 250 adults will receive either ixekizumab alone or both drugs together for up to 61 weeks. The goal is to see if the combination leads to clearer skin and significant weight reduction.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

281 people

The number who actually took part.

Started

Sep 2024

Finished

Jun 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have a diagnosis of moderate-to-severe plaque psoriasis (PsO) for at least 6 months. * Have both a Static Physician's Global Assessment (sPGA) score of ≥3 and a Psoriasis Area and Severity Index (PASI) ≥12. * Have ≥10% body surface area (BSA) involvement. * Have obesity, body mass index of ≥30 kilograms per meter squared (BMI ≥30 kg/m²) or overweight (BMI ≥27 to \<30 kg/m²) in the presence of at least 1 of these weight-related comorbid conditions (hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease, or T2DM). Exclusion Criteria: Medical Conditions * Have Type 1 Diabetes Mellitus (T1DM). * Have insulin-treated Type 2 Diabetes Mellitus (T2DM). * Have a prior or planned surgical treatment for obesity. * Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia (MEN) syndrome type 2. * Have active, or a history of inflammatory bowel disease (Crohn's or ulcerative colitis). * Have a diagnosis or history of malignant disease within the 5 years prior to randomization, with the following exceptions: * basal cell or squamous epithelial carcinomas of the skin that have been resected, with no evidence of metastatic disease for 3 years. * cervical carcinoma in situ, with no evidence of recurrence within the 5 years prior to randomization. * Have serious disorder or illness other than PsO. * Have a history of chronic or acute pancreatitis. * Have any prior use of ixekizumab or tirzepatide. * Have a previous failure or intolerance to an interleukin 17 inhibitor (IL-17i) or glucagon-like peptide 1 (GLP-1) receptor agonists.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Obesity are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

Obesity obesity disorder psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity Psoriasis

Contacts and locations

Locations

  • ActivMed Practices & Research, LLC.

    Portsmouth, New Hampshire, 03801, United States

  • Alliance for Multispecialty Research, LLC

    Fort Myers, Florida, 33912, United States

  • Austin Institute for Clinical Research

    Pflugerville, Texas, 78660, United States

  • Avance Clinical Trials

    Laguna Niguel, California, 92677, United States

  • Bellaire Dermatology Associates

    Bellaire, Texas, 77401, United States

  • Bellevue Dermatology Clinic

    Bellevue, Washington, 98004, United States

  • California Dermatology & Clinical Research Institute

    Encinitas, California, 92024, United States

  • Care Access - Arlington

    Arlington, Virginia, 22206, United States

  • Care Access - Danville

    Danville, Virginia, 24541, United States

  • Care Access - Hoboken

    Hoboken, New Jersey, 07030, United States

  • Care Access - Lake Charles (Bayou Pines)

    Lake Charles, Louisiana, 70601, United States

  • Columbia Dermatology & Aesthetics

    Columbia, South Carolina, 29212, United States

  • Cura Clinical Research - Oxnard

    Oxnard, California, 93030, United States

  • Dawes Fretzin Clinical Research Group, LLC

    Indianapolis, Indiana, 46250, United States

  • DeNova Research

    Chicago, Illinois, 60602, United States

  • DelRicht Research

    Baton Rouge, Louisiana, 70809, United States

  • DelRicht Research - Thompson's Station

    Smyrna, Tennessee, 37167, United States

  • Deluxe Health Center

    Miami Lakes, Florida, 33014, United States

  • Dermatologists of Southwest Ohio

    Mason, Ohio, 45040, United States

  • Dermatology Associates of Plymouth Meeting

    Plymouth Meeting, Pennsylvania, 19462, United States

  • Dermatology Clinical Research Center of San Antonio

    San Antonio, Texas, 78229, United States

  • Dermatology Research Associates

    Los Angeles, California, 90045, United States

  • Dermatology and Skin Cancer Specialists, LLC

    Rockville, Maryland, 20850, United States

  • Dermatology of Seattle

    Burien, Washington, 98168, United States

  • Encore Medical Research

    Hollywood, Florida, 33024, United States

  • Equity Medical

    New York, New York, 10023, United States

  • Equity Medical - Bowling Green

    Bowling Green, Kentucky, 42104, United States

  • First OC Dermatology Research Inc

    Fountain Valley, California, 92708, United States

  • GCM Medical Group, PSC - Hato Rey Site

    San Juan, 00917, Puerto Rico

  • Great Lakes Research Group, Inc.

    Bay City, Michigan, 48706, United States

  • Integrative Skin Science and Research - Location 2

    Sacramento, California, 95815, United States

  • International Clinical Research - Sanford

    Sanford, Florida, 32771, United States

  • International Clinical Research - Tennessee LLC

    Murfreesboro, Tennessee, 37130, United States

  • Johnson Dermatology

    Fort Smith, Arkansas, 72916, United States

  • Las Vegas Dermatology

    Las Vegas, Nevada, 89144, United States

  • Lawrence J. Green, MD, LLC

    Rockville, Maryland, 20850, United States

  • Leading Edge Dermatology

    Plantation, Florida, 33317, United States

  • Life Clinical Trials

    Coral Springs, Florida, 33071, United States

  • MI Skin Innovations

    Northville, Michigan, 48167, United States

  • Medical Dermatology Specialists

    Phoenix, Arizona, 85006, United States

  • Metropolis Dermatology

    Los Angeles, California, 90017, United States

  • Mindful Medical Research

    San Juan, 00918, Puerto Rico

  • Modern Research Associates, PLLC

    Dallas, Texas, 75231, United States

  • Mount Sinai Doctors - East 85th Street

    New York, New York, 10028, United States

  • NeoClinical Research

    Hialeah, Florida, 33016, United States

  • Nodal Medical Center

    Tampa, Florida, 33607, United States

  • Northridge Clinical Trials

    Northridge, California, 91325, United States

  • Oak Dermatology

    Naperville, Illinois, 60563, United States

  • Office of Dr. Alma M. Cruz

    Carolina, 00985, Puerto Rico

  • Onsite Clinical Solutions - Huntersville

    Huntersville, North Carolina, 28078, United States

  • Optima Research - Boardman

    Boardman, Ohio, 44512, United States

  • Oregon Dermatology and Research Center

    Portland, Oregon, 97210, United States

  • Oregon Medical Research Center

    Portland, Oregon, 97201, United States

  • Palm Harbor Dermatology PA d/b/a TrueBlue Clinical Research

    Tampa, Florida, 33609, United States

  • Progressive Clinical Research

    San Antonio, Texas, 78213, United States

  • Psoriasis Treatment Center of Central New Jersey

    East Windsor, New Jersey, 08520, United States

  • Red River Research Partners

    Fargo, North Dakota, 58103, United States

  • Renstar Medical Research

    Ocala, Florida, 34470, United States

  • SCB Research Center

    Bayamón, 00961, Puerto Rico

  • Scottsdale Clinical Trials

    Scottsdale, Arizona, 85260, United States

  • Skin Cancer and Dermatology Institute - Reno

    Reno, Nevada, 89509, United States

  • Skin Care Research

    Hollywood, Florida, 33021, United States

  • Solutions Through Advanced Research

    Jacksonville, Florida, 32256, United States

  • Tanner Clinic

    Layton, Utah, 84041, United States

  • Tekton Research - Westlake Drive

    Austin, Texas, 78746, United States

  • Texas Dermatology and Laser Specialists

    San Antonio, Texas, 78218, United States

  • The Derm Institute of West Michigan

    Caledonia, Michigan, 49316, United States

  • The Indiana Clinical Trials Center, PC

    Plainfield, Indiana, 46168, United States

  • Therapeutics Clinical Research

    San Diego, California, 92123, United States

  • Total Skin & Beauty Dermatology Center, PC DBA Total Dermatology

    Birmingham, Alabama, 35203, United States

  • Virginia Clinical Research, Inc.

    Norfolk, Virginia, 23502, United States

  • Yuma Clinical Trials

    Yuma, Arizona, 85365, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.