Brain scans reveal how psilocybin affects depression
NCT ID NCT06072898
First seen Apr 06, 2026 · Last updated Jun 23, 2026 · Updated 13 times
Summary
This study uses brain scans to see if psilocybin changes activity in mood-related brain networks in people with depression. Fifty adults will receive either psilocybin or a placebo pill, along with supportive therapy, and undergo MRI scans. The goal is to understand how psilocybin affects brain function, not to test it as a treatment.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Sunnybrook Health Sciences Centre
RECRUITINGToronto, Ontario, M4N3M5, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
psilocybin
What this could lead to
If it works, this could reveal how psilocybin affects mood-related brain circuits, pointing toward new ways to treat depression.
What could go wrong
This is a small, early-phase imaging study, not a treatment trial. It may not show clear brain changes or translate into a real-world therapy.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.