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Could a shot of your own blood beat botox for bladder control?

NCT ID NCT07184307

Disease control Sponsor: Benha University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether injecting platelet-rich plasma (PRP) into the bladder wall can help people with overactive bladder that hasn't improved with standard treatments. PRP, made from a patient's own blood, is compared to Botox, a common treatment for this condition. About 48 adults will be randomly assigned to receive either PRP or Botox injections, and their symptoms will be tracked for one year to see which treatment works better and lasts longer.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Platelet-rich plasma (PRP) or botulinum toxin (Botox)
What this could lead to
If PRP works as well as Botox with fewer side effects and longer-lasting results, it could offer a new, natural treatment option for people with stubborn overactive bladder.
What could go wrong
This is a small, early-stage study with only 48 participants. PRP is experimental for this use, and it may not prove as effective or durable as hoped. There is also a risk of side effects like infection or temporary difficulty emptying the bladder.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 48 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Apr 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older * History of urgency, frequency, nocturia, with or without urge urinary incontinence, lasting for at least 6 months * Failure of standard medical treatment (antimuscarinics, beta-3 adrenergic agonists, or other appropriate therapy) for at least 6 months * Willing and able to complete bladder diaries, questionnaires, and urodynamic testing * Provides informed consent Exclusion Criteria: * Pregnancy or lactation * Previous intravesical biological therapy (e.g., platelet-rich plasma or botulinum toxin) * Prior pelvic or bladder surgery that may affect bladder function * Active urinary tract infection or sexually transmitted infection * Vaginitis or chronic bacterial prostatitis * Bladder or lower ureteral stones confirmed by imaging * Bladder outlet obstruction on urodynamic study * Bladder malignancy (mass on imaging or malignant cells on cytology) * Use of indwelling urinary catheter * Severe uncontrolled medical conditions (e.g., uncontrolled diabetes, advanced renal or hepatic impairment) * Known hypersensitivity to botulinum toxin or contraindication to platelet-rich plasma preparation (e.g., coagulopathy, inability to discontinue anticoagulation safely)

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Conditions

The condition(s) this trial relates to.

overactive bladder Urinary Incontinence, Urge

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Detrusor overactivity Overactive bladder syndrome Urinary urge incontinence

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Benha University Hospital, Faculty of Medicine, Department of Urology

    RECRUITING

    Banhā, Qalyubia Governorate, 13511, Egypt

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