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Can your own blood straighten the curve? PRP takes on Peyronie's

NCT ID NCT04512287

Disease control Sponsor: University of Miami Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This trial tests whether injecting platelet-rich plasma (PRP) — a concentrate made from a person's own blood — into the penile plaque can reduce curvature and ease symptoms in men with Peyronie's disease. Half the participants receive PRP injections and half receive a placebo (saline), with the option to cross over. The study measures changes in penile curvature and symptom scores to see if PRP offers a safe, non-surgical treatment option.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Autologous platelet-rich plasma (PRP) injected into the penile plaque
What this could lead to
If effective, PRP injections could offer a non-surgical option to reduce penile curvature and improve symptoms in men with Peyronie's disease.
What could go wrong
This is a small phase 2 trial, so results may not be conclusive. PRP is experimental for this condition, and its benefits are uncertain. Risks include injection-related discomfort or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

65 people

The number who actually took part.

Started

Mar 2021

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Be Male 2. Be 18 to 75 years of age (inclusive). 3. Be able to provide written informed consent 4. Have a diagnosis of PD with evidence of active or stable disease as determined by the investigator 5. Penile curvature deformity of \>30° to \<120° 6. Agree to comply with all study related tests/procedures. Exclusion Criteria: 1. Previous penile surgery of any kind (except circumcision and condyloma removal), such as penile lengthening, penile cancer surgery, penile plication, grafting. 2. Previous intralesional injection therapy (such as Xiaflex) for PD. 3. Previous history of priapism or penile fracture 4. PD characterized by a ventral plaque 5. Severe erectile dysfunction as characterized with an International Index of Erectile Function (IIEF) score ≤ 16 6. Actively on anticoagulation during time frame of injections (aspirin 81 mg will be eligible for therapy) 7. Hour-glass deformity 8. Unwilling to participate 9. Medically unfit for sexual intercourse as deemed by the principal investigator 10. Patients scheduled to undergo an elective medical procedure during the investigation timeframe that will interfere with autologous PRP injection therapy. 11. Have a serious comorbid illness/condition/behavior that, in the opinion of the investigator, may compromise the safety or compliance of the subject or preclude successful completion of the study.

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Conditions

The condition(s) this trial relates to.

male reproductive system disorder Penile Induration Peyronie disease physiological sexual disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Genital diseases, male Peyronie disease Sexual dysfunction male Sexual dysfunction, physiological

Contacts and locations

Locations

  • University of Miami

    Miami, Florida, 33136, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.