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New proton therapy strategy aims to shrink side effects for young brain tumor patients

NCT ID NCT01419067

Disease control Sponsor: St. Jude Children's Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Aug 20, 2026 · Updated 3 times

Summary

This study tests whether using limited surgery followed by proton therapy can control craniopharyngioma, a rare brain tumor, in children and young adults. The goal is to reduce radiation side effects by using a tighter radiation margin. Some patients who have complete tumor removal by surgery are simply watched without radiation. The trial tracks how long patients stay free of tumor growth and overall survival.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
proton therapy
What this could lead to
If successful, this approach could offer a way to control craniopharyngioma with fewer long-term side effects than standard radiation.
What could go wrong
This is a phase II trial with a moderate number of participants, so results may not apply to everyone. There is still a risk of tumor progression or side effects from treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

112 people

The number who actually took part.

Started

Aug 2011

Expected to finish

Jun 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Up to 21 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Craniopharyngioma diagnosed by histology, cytology or neuroimaging. * Patients ages 0-21 years at the time of diagnosis. Exclusion Criteria * Prior history of fractionated radiation therapy. * Prior treatment with intracystic P-32, intracystic bleomycin or radiosurgery. * Pregnant females are excluded. Radiation has teratogenic or abortifacient effects.

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Conditions

The condition(s) this trial relates to.

craniopharyngioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Craniopharyngioma

Contacts and locations

Locations

  • St. Jude Children's Research Hospital

    Memphis, Tennessee, 38105, United States

  • University of Florida Health Proton Therapy Institute

    Jacksonville, Florida, 32206, United States

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